Table 2 The expression, clinical significance and biological functions of IGF2BP2 in different cancer types
From: The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers
Cancer | Expression | Role | Biological function | Upstream | Target | Refs. |
|---|---|---|---|---|---|---|
AML | ↑ | Oncogene | Cell growth |  | / | [65] |
Breast cancer | / | Oncogene | Proliferation, invasion | miR-1193 | ERK, PI3K/Akt | [7] |
↑ | Oncogene | / | / | / | [14] | |
↑ | Oncogene | Autoantibody response | / | / | [73] | |
↑ | Oncogene | Tumor growth | CCN6 | / | [74] | |
Colorectal cancer | ↑ | Oncogene | Proliferation, survival | / | miR-195/RAF1 | [81] |
/ | Oncogene | Invasion, proliferation, migration, MDV, EMT, apoptosis | LncRNA HOTAIR | / | [9] | |
/ | Oncogene | Glycolysis, proliferation | LINRIS | MYC | [100] | |
/ | / | Proliferation, migration, invasion, autophagy | 91H | IGF2 | [103] | |
/ | / | Cell self-renewal, stem cell frequency, migration, tumorigenesis, metastasis | METTL3 | SOX2 | [15] | |
Glioma | / | / | Proliferation, migration, invasion | miR-188 | / | [91] |
↑ | Oncogene | Proliferation, invasion | miR-138 | / | [17] | |
HCC | ↑ | Oncogene | Proliferation, migration, invasion | miR-216b | / | [92] |
/ | Oncogene | Proliferation, metastasis | lncRNA RHPN1-AS1/miR-596 | / | [104] | |
/ | / | / | MIRLRT7A3/miR-let-7a | / | [18] | |
|  | ↑ | Oncogene | Proliferation | FEN1 |  | [66] |
Lung cancer | / | / | Growth, invasion, cell cycle | miR-485-5p | / | [95] |
HNSCC | ↑ | Oncogene | Scavenging and degradation, synthesis and metabolism, cell growth, death and motility | / | / | [67] |
PDAC | ↑ | Oncogene | Aerobic glycolysis, proliferation | / | GLUT1 | [68] |
↑ | Oncogene | Cell growth | miR-141 | PI3K/Akt | [20] | |
↑ | Oncogene | Proliferation, stemness-like properties |  | LncRNA DANCR | [70] | |
GBC | ↑ | Oncogene | Tumor growth | / | / | [71] |
ERMS | / | / | Survival and growth | HMGA2 | NRAS | [85] |