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Table 2 The expression, clinical significance and biological functions of IGF2BP2 in different cancer types

From: The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

Cancer

Expression

Role

Biological function

Upstream

Target

Refs.

AML

Oncogene

Cell growth

 

/

[65]

Breast cancer

/

Oncogene

Proliferation, invasion

miR-1193

ERK, PI3K/Akt

[7]

Oncogene

/

/

/

[14]

Oncogene

Autoantibody response

/

/

[73]

Oncogene

Tumor growth

CCN6

/

[74]

Colorectal cancer

Oncogene

Proliferation, survival

/

miR-195/RAF1

[81]

/

Oncogene

Invasion, proliferation, migration, MDV, EMT, apoptosis

LncRNA HOTAIR

/

[9]

/

Oncogene

Glycolysis, proliferation

LINRIS

MYC

[100]

/

/

Proliferation, migration, invasion, autophagy

91H

IGF2

[103]

/

/

Cell self-renewal, stem cell frequency, migration, tumorigenesis, metastasis

METTL3

SOX2

[15]

Glioma

/

/

Proliferation, migration, invasion

miR-188

/

[91]

Oncogene

Proliferation, invasion

miR-138

/

[17]

HCC

Oncogene

Proliferation, migration, invasion

miR-216b

/

[92]

/

Oncogene

Proliferation, metastasis

lncRNA RHPN1-AS1/miR-596

/

[104]

/

/

/

MIRLRT7A3/miR-let-7a

/

[18]

 

Oncogene

Proliferation

FEN1

 

[66]

Lung cancer

/

/

Growth, invasion, cell cycle

miR-485-5p

/

[95]

HNSCC

Oncogene

Scavenging and degradation, synthesis and metabolism, cell growth, death and motility

/

/

[67]

PDAC

Oncogene

Aerobic glycolysis, proliferation

/

GLUT1

[68]

Oncogene

Cell growth

miR-141

PI3K/Akt

[20]

Oncogene

Proliferation, stemness-like properties

 

LncRNA DANCR

[70]

GBC

Oncogene

Tumor growth

/

/

[71]

ERMS

/

/

Survival and growth

HMGA2

NRAS

[85]

  1. ↑: indicate up-regulated
  2. AML acute myelocytic leukemia, RAF1 rubisco assembly factor 1, SOX2 SRY (sex determining region Y)-box 2, GLUT1 glucose transporter 1