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Table 2 The expression, clinical significance and biological functions of IGF2BP2 in different cancer types

From: The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

Cancer Expression Role Biological function Upstream Target Refs.
AML Oncogene Cell growth   / [65]
Breast cancer / Oncogene Proliferation, invasion miR-1193 ERK, PI3K/Akt [7]
Oncogene / / / [14]
Oncogene Autoantibody response / / [73]
Oncogene Tumor growth CCN6 / [74]
Colorectal cancer Oncogene Proliferation, survival / miR-195/RAF1 [81]
/ Oncogene Invasion, proliferation, migration, MDV, EMT, apoptosis LncRNA HOTAIR / [9]
/ Oncogene Glycolysis, proliferation LINRIS MYC [100]
/ / Proliferation, migration, invasion, autophagy 91H IGF2 [103]
/ / Cell self-renewal, stem cell frequency, migration, tumorigenesis, metastasis METTL3 SOX2 [15]
Glioma / / Proliferation, migration, invasion miR-188 / [91]
Oncogene Proliferation, invasion miR-138 / [17]
HCC Oncogene Proliferation, migration, invasion miR-216b / [92]
/ Oncogene Proliferation, metastasis lncRNA RHPN1-AS1/miR-596 / [104]
/ / / MIRLRT7A3/miR-let-7a / [18]
  Oncogene Proliferation FEN1   [66]
Lung cancer / / Growth, invasion, cell cycle miR-485-5p / [95]
HNSCC Oncogene Scavenging and degradation, synthesis and metabolism, cell growth, death and motility / / [67]
PDAC Oncogene Aerobic glycolysis, proliferation / GLUT1 [68]
Oncogene Cell growth miR-141 PI3K/Akt [20]
Oncogene Proliferation, stemness-like properties   LncRNA DANCR [70]
GBC Oncogene Tumor growth / / [71]
ERMS / / Survival and growth HMGA2 NRAS [85]
  1. ↑: indicate up-regulated
  2. AML acute myelocytic leukemia, RAF1 rubisco assembly factor 1, SOX2 SRY (sex determining region Y)-box 2, GLUT1 glucose transporter 1
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