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Fig. 1 | Cancer Cell International

Fig. 1

From: ABCB1 and ABCG2 restricts the efficacy of gedatolisib (PF-05212384), a PI3K inhibitor in colorectal cancer cells

Fig. 1

Anti-proliferation effects of gedatolisib in parental and ABCB1- or ABCG2-overexpression cells. a Chemical structure of gedatolisib. b Dose-viability curves of SW620 and SW620/ADR cells after treatment with different concentration of gedatolisib for 72 h. c Dose-viability curves of LS180 and LS180/MX cells after treatment with different concentration of gedatolisib for 72 h. d Dose-viability curves of HEK293/pcDNA3.1, HEK293/ABCB1, and HEK293/ABCG2 cells after treatment with different concentration of gedatolisib for 72 h. e Confirmation of overexpression of ABCB1 or ABCG2 in drug-selected and DNA-transfected cell lines. Data were shown with mean ± SD, which is representative for at least three independent experiments

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