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Table 1 Differences in the levels of candidate marker proteins among the patient groups

From: Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer

Name of protein

Peptide sequence

HSIL vs normal control

CSCC vs normal control

CSCC vs HSIL

Comparisons between the 3 groups

Peptide ratio

P-value

Protein expression rate

Peptide ratio

P-value

Protein expression rate

Peptide ratio

P-value

Protein expression rate

P- value

sp|P23142|FBLN1-1_HUMAN

SQETGDLDVGGLQETDK

0.739

0.055

0.705

0.862

0.192

0.815

1.166

0.285

1.157

0.109

FBLN1-2_HUMAN

IIEVEEEQEDPYLNDR

0.670

0.010*

 

0.769

0.025*

 

1.148

0.364

 

0.015*

sp|P02649|APOE-1_HUMAN

SELEEQLTPVAEETR

1.057

0.854

0.9374

0.631

0.091

0.8355

0.597

0.053

0.9344

0.140

APOE-2_HUMAN

LAVYQAGAR

0.818

0.153

 

1.041

0.800

 

1.272

0.239

 

0.379

sp|P06727|APOA4-1_HUMAN

LGEVNTYAGDLQK

0.740

0.069

0.733

0.727

0.027*

0.816

0.983

0.906

1.114

0.041*

APOA4-2_HUMAN

IDQNVEELK

0.727

0.069

 

0.904

0.408

 

1.244

0.130

 

0.122

tr|Q6P5S8|IGKα_HUMAN

VDNALQSGNSQESVTEQDSK

0.852

0.228

0.852

0.863

0.108

0.863

1.013

0.910

1.013

0.255

Sp|P01008|ANT3-1_HUMAN

TSDQIHFFFAK

0.676

0.034*

0.622

0.808

0.096

0.759

1.196

0.273

1.222

0.052

ANT3-2_HUMAN

VAEGTQVLELPFK

0.569

0.036*

 

0.710

0.044*

 

1.249

0.232

 

0.025*

sp|P02647|APOA1-1_HUMAN

DLATVYVDVLK

0.963

0.886

0.851

1.081

0.744

0.959

1.123

0.661

1.127

0.890

APOA1-2_HUMAN

VSFLSALEEYTK

0.740

0.076

 

0.837

0.185

 

1.132

0.392

 

0.140

  1. Additional file 6: Fig. S1 ROC curves obtained of four candidate marker proteins to distinguish between HSIL (CIN II + III) and cervical cancer (CC) and the control group (normal control, NC)
  2. Additional file 8: Fig. S2 The concentration of four candidate marker proteins in 284 specimens from the three patient groups (CIN II + III, CC and NC)
  3. Additional file 6: Fig. S3. Volcano Plots of (A) C33/Siha cells, (B) Siha/Caski cells and (C) C33/Caski cells
  4. Additional file 11: Fig. S4. Numbers and percentages of 729 proteins common to the secretomes of cervical carcinoma cell lines occurring in the indicated Gene Ontology categories