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Table 1 Differences in the levels of candidate marker proteins among the patient groups

From: Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer

Name of protein Peptide sequence HSIL vs normal control CSCC vs normal control CSCC vs HSIL Comparisons between the 3 groups
Peptide ratio P-value Protein expression rate Peptide ratio P-value Protein expression rate Peptide ratio P-value Protein expression rate P- value
sp|P23142|FBLN1-1_HUMAN SQETGDLDVGGLQETDK 0.739 0.055 0.705 0.862 0.192 0.815 1.166 0.285 1.157 0.109
FBLN1-2_HUMAN IIEVEEEQEDPYLNDR 0.670 0.010*   0.769 0.025*   1.148 0.364   0.015*
sp|P02649|APOE-1_HUMAN SELEEQLTPVAEETR 1.057 0.854 0.9374 0.631 0.091 0.8355 0.597 0.053 0.9344 0.140
APOE-2_HUMAN LAVYQAGAR 0.818 0.153   1.041 0.800   1.272 0.239   0.379
sp|P06727|APOA4-1_HUMAN LGEVNTYAGDLQK 0.740 0.069 0.733 0.727 0.027* 0.816 0.983 0.906 1.114 0.041*
APOA4-2_HUMAN IDQNVEELK 0.727 0.069   0.904 0.408   1.244 0.130   0.122
tr|Q6P5S8|IGKα_HUMAN VDNALQSGNSQESVTEQDSK 0.852 0.228 0.852 0.863 0.108 0.863 1.013 0.910 1.013 0.255
Sp|P01008|ANT3-1_HUMAN TSDQIHFFFAK 0.676 0.034* 0.622 0.808 0.096 0.759 1.196 0.273 1.222 0.052
ANT3-2_HUMAN VAEGTQVLELPFK 0.569 0.036*   0.710 0.044*   1.249 0.232   0.025*
sp|P02647|APOA1-1_HUMAN DLATVYVDVLK 0.963 0.886 0.851 1.081 0.744 0.959 1.123 0.661 1.127 0.890
APOA1-2_HUMAN VSFLSALEEYTK 0.740 0.076   0.837 0.185   1.132 0.392   0.140
  1. Additional file 6: Fig. S1 ROC curves obtained of four candidate marker proteins to distinguish between HSIL (CIN II + III) and cervical cancer (CC) and the control group (normal control, NC)
  2. Additional file 8: Fig. S2 The concentration of four candidate marker proteins in 284 specimens from the three patient groups (CIN II + III, CC and NC)
  3. Additional file 6: Fig. S3. Volcano Plots of (A) C33/Siha cells, (B) Siha/Caski cells and (C) C33/Caski cells
  4. Additional file 11: Fig. S4. Numbers and percentages of 729 proteins common to the secretomes of cervical carcinoma cell lines occurring in the indicated Gene Ontology categories