Table 2 Tumor suppressive lncRNAs in renal cell carcinoma

MEG3

Is decreased in human RCC tissues; up-regulates RASL11B expression by competing with miR-7; reduces RCC cell proliferation, migration and invasion and induces RCC cell apoptosis

[10]

lncPENG

Is expressed at lower levels in human RCC tissues with the down-regulation correlating with worse patient prognosis; binds to miR-15b to up-regulate PDZK1 expression; suppresses RCC cell proliferation in vitro and in vivo

[11]

lncRNA-LET

Is expressed at lower levels in human RCC tissues; competes with miR-373-3p to block DKK1 and TIMP2 down-regulation; induces RCC cell cycle arrest and apoptosis; blocks RCC tumor growth in mice

[58]

KCNQ1DN

Is down-regulated in human RCC tissues; reduces c-Myc and cyclin D1 and up-regulates p27; suppresses RCC cell proliferation and cell cycle progression; suppresses RCC tumor growth

[59]

OTUD6B-AS1

Is down-regulated in human RCC tissues with the down-regulation correlating with poor patient prognosis; blocks Wnt/β-catenin pathway, reduces EMT-related proteins; suppresses RCC cell proliferation, survival, migration and invasion in vitro and tumor growth in mice

[60]

LncRNA-SARCC

Is silenced in human RCC tissues with the down-regulation predicting worse patient prognosis; destabilizes androgen receptor; de-represses miR-143-3p; inactivates ERK, AKT, MMP-13 and K-RAS; reduces RCC cell proliferation, migration and invasion in vitro and in mice

[61, 62]

FILNC1

Is down-regulated in RCC tissues with the down-regulation correlating with worse patient prognosis; downregulates c-Myc protein translation; reduces glucose uptake and lactate production; induces energy stress-induced apoptosis and suppresses RCC progression in vivo

[63]