Fig. 1
From: The biological function of m6A reader YTHDF2 and its role in human disease
The role of YTHDF2 in human cancers and non-cancers. YTHDF2 took a great part in prostate cancer, bladder cancer, hepatocellular carcinoma, cervical cancer, osteosarcoma, AML and pancreatic cancer through modulating miR-403-3p, SETD7, KLF4, SOCS2, OCT4, IL11, SERPINE2, MEK, ERK, EGFR, CDK1, WEE1, circ0001105, PER1 and ATM-CHK2-P53/CDC25C. The modulation processes were closely related with tumor cell migration, invasion, metastasis, proliferation, apoptosis, cell cycle, cell viability and inflammation. In addition, YTHDF2 played an important role in hematopoietic stem cells, pluripotent stem cells, adipogenesis, virus infection, and male and female fertility by regulating proliferation-related genes, survival-related genes, neural-specific gene, JAK1/2, SOCS3, CCNA2, CDK2, FAM134B, Tnfrsf2, ORF50 and MMPs. The regulation process were strongly related with cell self-renewal, regenerative, differentiation, proliferation, MCE, cell cycle, apoptosis and cell adhesion