The biological function of m6A reader YTHDF2 and its role in human disease

Table 1 Expression, role, biological function and potential targets of YTHDF2 in cancers

Cancer	Expression	Role	Biological function	Target	Ref
Bladder Cancer	↑	Oncogene	Migration	SETD7 and KLF4	[21]
Hepatocellular Carcinoma	−	Oncogene		SOCS2	[33]
	−	Oncogene	CSC liver phenotype, metastasis	OCT4	[34]
	↓	Tumor suppressor	Inflammation, vasculature remodeling, metastasis	IL11, SERPINE2	[35]
	↓	Tumor suppressor	Proliferation, tumor growth	EGFR	[36]
Cervical Cancer	↑	Oncogene	Proliferation, apoptosis, cell cycle	-	[38]
Gastric Cancer	↑	Oncogene	Proliferation, cell cycle, apoptosis	-	[40]
Osteosarcoma	↓	Tumor suppressor	Cell viability, invasion, tumor growth		[42]
Pancreatic Cancer	−	Oncogene	Proliferation, migration, invasion Tumor growth, metastasis	PER1	[44]
Prostate Cancer	↑	Oncogene	Proliferation, migration	miR-493-3p	[46]

ISSN: 1475-2867