LINC00221 silencing prevents the progression of hepatocellular carcinoma through let-7a-5p-targeted inhibition of MMP11

Table 3 The correlation of LINC00221 expression with the progression of HCC

Clinicopathological characteristics	Case	LINC00221 expression	p
Age (years)			0.689
≤ 45	16	3.076 ± 0.714
> 45	29	3.148 ± 0.512
Gender			0.824
Male	26	3.139 ± 0.540
Female	19	3.099 ± 0.654
Tumor size			0.443
≤ 5 cm	17	3.035 ± 0.631
> 5 cm	28	3.175 ± 0.560
Tumor number			0.282
Single	30	3.055 ± 0.522
Multiple	15	3.256 ± 0.693
Clinical grade			0.001
I/II	21	2.822 ± 0.704
III	24	3.385 ± 0.262
TNM stage			0.005
I/II	28	2.936 ± 0.639
III	17	3.429 ± 0.300
LNM			0.001
Yes	11	3.517 ± 0.593
No	34	2.994 ± 0.336
AFP (ng/mL)			< 0.001
≤ 200	21	2.824 ± 0.706
> 200	24	3.383 ± 0.262

HCC hepatocellular carcinoma, TNM tumor node metastasis, LNM lymph node metastasis, AFP alpha-fetoprotein

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