Fig. 1
From: Targeting Nrf2 may reverse the drug resistance in ovarian cancer
Structure of the human Nrf2 protein. The Neh1 domain consists of the CNC-bZIP region, in which DNA binds the sMaf proteins as Nrf2 dimerization partners. The Neh2 domain contains two sites, named as DLG and ETGE, which combine with the cytoplasmic protein Keap1, a negative regulator of Nrf2 transcriptional activity. Neh3–5 can bind with coactivating factors and are transactivating structural domains of Nrf2.Neh6 is a serine-rich region associated with the negative regulation of Nrf2 stability, which relies on Keap1. Neh7 containing the retinoid X receptor inhibits the transcriptional activity of Nrf2