Fig. 3
From: Targeting Nrf2 may reverse the drug resistance in ovarian cancer
Various drug resistance mechanisms associated with Nrf2. SIRT5,CD99,ABCG2/HO-2,HER1,HER2/HER3,ABCF2,GPX4,AKR1C1 and CBS have a positive relationship with Nrf2 as molecules regulated by Nrf2 or regulating Nrf2;while ATF and SLC40A1 have a negative relationship with Nrf2; As the transcription target of Nrf2, p62/SQSTM1 competes with Nrf2 for binding with Keap1 and form a positive feedback loop between p62 and Nrf2.(“→” represents “activation” “— ” means “inhibition”.)