Fig. 4

Prognostic impact of immune subtypes and immune signatures. a Overall survival of three immune subtypes. b Correlation of immune signatures with overall survival. The Left was for IFN-γ module. The Right was for Wound healing module. c Multivariate COX analysis of three immune signatures. Wound healing module (coef = 1.45, HR = 4.28, 95%CI 1.03–17.67, p = 0.045), IFN-γ module (coef = 0.57, HR = 1.77, 95%CI 1.03–3.06, p = 0.04), TGF-β module (coef = 1.16, HR = 3.21, 95%CI 0.99–10.34, p = 0.051). d Concordance index (CI) of five immune signature expression with the overall survival. Columns and rows represented immune subtypes and immune signatures respectively. Red indicated higher prediction accuracy while blue indicated lower prediction accuracy, along with the increasing expression of immune signature enrichment scores