Identification of key genes involved in tumor immune cell infiltration and cetuximab resistance in colorectal cancer

Liang, Li; Liu, Mengling; Sun, Xun; Yuan, Yitao; Peng, Ke; Rashid, Khalid; Yu, Yiyi; Cui, Yuehong; Chen, Yanjie; Liu, Tianshu

doi:10.1186/s12935-021-01829-8

Table 2 GO term and KEGG pathway enrichment analyses of differentially expressed genes

From: Identification of key genes involved in tumor immune cell infiltration and cetuximab resistance in colorectal cancer

Term	Description	Count	%	Log₁₀ [p value]	Log₁₀ [q value]
GO Biological process
GO:0006935	Chemotaxis	117	5.89	−15.44	−11.44
GO:0010817	Regulation of hormone levels	102	5.13	−15.05	−11.33
GO:1,901,615	Organic hydroxy compound metabolic process	100	5.03	−13.61	−10.01
GO:0043062	Extracellular structure organization	82	4.13	−12.37	−8.87
GO:0015711	Organic anion transport	85	4.28	−10.60	−7.25
GO:0072006	Nephron development	37	1.86	−9.56	−6.40
GO:0048514	Blood vessel morphogenesis	105	5.28	−9.29	−6.20
GO:0009611	Response to wounding	105	5.28	−9.25	−6.20
GO:0051047	Positive regulation of secretion	75	3.77	−9.14	−6.11
GO:0006869	Lipid transport	66	3.32	−9.03	−6.06
GO:0008285	Negative regulation of cell proliferation	113	5.69	−8.91	−6.01
GO:0052548	Regulation of endopeptidase activity	73	3.67	−8.70	−5.86
GO:0032787	Monocarboxylic acid metabolic process	97	4.88	−8.15	−5.36
GO:0008610	Lipid biosynthetic process	103	5.18	−7.83	−5.11
GO:0003013	Circulatory system process	83	4.18	−7.17	−4.54
GO:0048598	Embryonic morphogenesis	87	4.38	−6.84	−4.26
GO:0030155	Regulation of cell adhesion	99	4.98	−6.68	−4.14
GO:0046683	Response to organophosphorus	31	1.56	−6.68	−4.14
GO:0035272	Exocrine system development	17	0.86	−6.62	−4.11
GO:0015718	Monocarboxylic acid transport	35	1.76	−6.53	−4.04
GO molecular function
GO:0008289	Lipid binding	104	5.23	−6.90	−3.45
GO:0004857	Enzyme inhibitor activity	62	3.12	−6.81	−3.45
GO:0005509	Calcium ion binding	97	4.88	−6.45	−3.37
GO:0008201	Heparin binding	34	1.71	−6.05	−3.17
GO:0008514	Organic anion transmembrane transporter activity	39	1.96	−5.75	−3.06
GO:0048018	Receptor ligand activity	70	3.52	−5.72	−3.06
GO:0000987	Proximal promoter sequence-specific DNA binding	84	4.23	−5.16	−2.65
GO:0016491	Oxidoreductase activity	95	4.78	−4.82	−2.41
GO:0005201	Extracellular matrix structural constituent	30	1.51	−4.52	−2.18
GO:0016298	Lipase activity	25	1.26	−4.46	−2.16
GO:0033293	Monocarboxylic acid binding	18	0.91	−4.39	−2.14
GO:0043178	Alcohol binding	19	0.96	−4.39	−2.14
GO:0015144	Carbohydrate transmembrane transporter activity	12	0.60	−4.35	−2.12
GO:0033764	Steroid dehydrogenase activity	10	0.50	−4.05	−1.90
GO:0030515	snoRNA binding	10	0.50	−4.05	−1.90
GO:0042803	Protein homodimerization activity	81	4.08	−4.04	−1.90
GO:0008233	Peptidase activity	78	3.93	−3.82	−1.73
GO:0004745	Retinol dehydrogenase activity	8	0.40	−3.80	−1.73
GO:0019955	Cytokine binding	24	1.21	−3.69	−1.63
GO:0015250	Water channel activity	6	0.30	−3.50	−1.46
GO cellular component
GO:0031012	Extracellular matrix	98	4.93	−13.46	−10.17
GO:0016324	Apical plasma membrane	68	3.42	−11.60	−8.79
GO:0044420	Extracellular matrix component	17	0.86	−6.08	−3.57
GO:0016323	Basolateral plasma membrane	41	2.06	−5.91	−3.52
GO:0031253	Cell projection membrane	56	2.82	−5.90	−3.52
GO:0005604	Basement membrane	23	1.16	−5.55	−3.21
GO:0031526	Brush border membrane	16	0.81	−5.25	−2.97
GO:0031091	Platelet alpha granule	21	1.06	−4.93	−2.72
GO:0030684	Pre-ribosome	19	0.96	−4.87	−2.70
GO:0005667	Transcription factor complex	53	2.67	−4.60	−2.46
GO:0070161	Anchoring junction	71	3.57	−3.64	−1.68
GO:0044452	Nucleolar part	29	1.46	−3.61	−1.67
GO:0005911	Cell-cell junction	53	2.67	−3.49	−1.60
GO:0005773	Vacuole	93	4.68	−3.40	−1.56
GO:0005777	Peroxisome	24	1.21	−3.40	−1.56
GO:0034358	Plasma lipoprotein particle	10	0.50	−3.32	−1.52
GO:0000940	Condensed chromosome outer kinetochore	6	0.30	−3.29	−1.52
GO:0071438	Invadopodium membrane	4	0.20	−3.22	−1.48
GO:0048471	Perinuclear region of cytoplasm	85	4.28	−3.20	−1.47
GO:0005593	FACIT collagen trimer	4	0.20	−2.88	−1.25
KEGG pathway
hsa04974	Protein digestion and absorption	23	1.16	−6.16	−3.46
hsa04060	Cytokine-cytokine receptor interaction	45	2.26	−5.38	−2.98
hsa00830	Retinol metabolism	17	0.86	−4.86	−2.64
hsa04510	Focal adhesion	34	1.71	−4.45	−2.36
hsa04918	Thyroid hormone synthesis	17	0.86	−4.08	−2.08
hsa04610	Complement and coagulation cascades	17	0.86	−3.71	−1.85
hsa04310	Wnt signaling pathway	24	1.21	−3.21	−1.49
hsa03320	PPAR signaling pathway	15	0.75	−3.18	−1.49
hsa05323	Rheumatoid arthritis	17	0.86	−3.02	−1.36
hsa05146	Amoebiasis	17	0.86	−2.70	−1.27
hsa04540	Gap junction	16	0.81	−2.69	−1.27
hsa00471	D-Glutamine and D-glutamate metabolism	3	0.15	−2.68	−1.27
hsa04978	Mineral absorption	11	0.55	−2.60	−1.21
hsa04146	Peroxisome	15	0.75	−2.53	−1.16
hsa04621	NOD-like receptor signaling pathway	25	1.26	−2.49	−1.14
hsa04390	Hippo signaling pathway	23	1.16	−2.42	−1.13
hsa00590	Arachidonic acid metabolism	12	0.60	−2.38	−1.13
hsa00564	Glycerophospholipid metabolism	16	0.81	−2.35	−1.12
hsa04976	Bile secretion	13	0.65	−2.32	−1.10
hsa05412	Arrhythmogenic right ventricular cardiomyopathy	13	0.65	−2.26	−1.06

GO, Gene Ontology. KEGG, Kyoto Encyclopedia of Genes and Genomes

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