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Table 2 GO term and KEGG pathway enrichment analyses of differentially expressed genes

From: Identification of key genes involved in tumor immune cell infiltration and cetuximab resistance in colorectal cancer

Term Description Count % Log10 [p value] Log10 [q value]
GO Biological process
 GO:0006935 Chemotaxis 117 5.89 −15.44 −11.44
 GO:0010817 Regulation of hormone levels 102 5.13 −15.05 −11.33
 GO:1,901,615 Organic hydroxy compound metabolic process 100 5.03 −13.61 −10.01
 GO:0043062 Extracellular structure organization 82 4.13 −12.37 −8.87
 GO:0015711 Organic anion transport 85 4.28 −10.60 −7.25
 GO:0072006 Nephron development 37 1.86 −9.56 −6.40
 GO:0048514 Blood vessel morphogenesis 105 5.28 −9.29 −6.20
 GO:0009611 Response to wounding 105 5.28 −9.25 −6.20
 GO:0051047 Positive regulation of secretion 75 3.77 −9.14 −6.11
 GO:0006869 Lipid transport 66 3.32 −9.03 −6.06
 GO:0008285 Negative regulation of cell proliferation 113 5.69 −8.91 −6.01
 GO:0052548 Regulation of endopeptidase activity 73 3.67 −8.70 −5.86
 GO:0032787 Monocarboxylic acid metabolic process 97 4.88 −8.15 −5.36
 GO:0008610 Lipid biosynthetic process 103 5.18 −7.83 −5.11
 GO:0003013 Circulatory system process 83 4.18 −7.17 −4.54
 GO:0048598 Embryonic morphogenesis 87 4.38 −6.84 −4.26
 GO:0030155 Regulation of cell adhesion 99 4.98 −6.68 −4.14
 GO:0046683 Response to organophosphorus 31 1.56 −6.68 −4.14
 GO:0035272 Exocrine system development 17 0.86 −6.62 −4.11
 GO:0015718 Monocarboxylic acid transport 35 1.76 −6.53 −4.04
GO molecular function
 GO:0008289 Lipid binding 104 5.23 −6.90 −3.45
 GO:0004857 Enzyme inhibitor activity 62 3.12 −6.81 −3.45
 GO:0005509 Calcium ion binding 97 4.88 −6.45 −3.37
 GO:0008201 Heparin binding 34 1.71 −6.05 −3.17
 GO:0008514 Organic anion transmembrane transporter activity 39 1.96 −5.75 −3.06
 GO:0048018 Receptor ligand activity 70 3.52 −5.72 −3.06
 GO:0000987 Proximal promoter sequence-specific DNA binding 84 4.23 −5.16 −2.65
 GO:0016491 Oxidoreductase activity 95 4.78 −4.82 −2.41
 GO:0005201 Extracellular matrix structural constituent 30 1.51 −4.52 −2.18
 GO:0016298 Lipase activity 25 1.26 −4.46 −2.16
 GO:0033293 Monocarboxylic acid binding 18 0.91 −4.39 −2.14
 GO:0043178 Alcohol binding 19 0.96 −4.39 −2.14
 GO:0015144 Carbohydrate transmembrane transporter activity 12 0.60 −4.35 −2.12
 GO:0033764 Steroid dehydrogenase activity 10 0.50 −4.05 −1.90
 GO:0030515 snoRNA binding 10 0.50 −4.05 −1.90
 GO:0042803 Protein homodimerization activity 81 4.08 −4.04 −1.90
 GO:0008233 Peptidase activity 78 3.93 −3.82 −1.73
 GO:0004745 Retinol dehydrogenase activity 8 0.40 −3.80 −1.73
 GO:0019955 Cytokine binding 24 1.21 −3.69 −1.63
 GO:0015250 Water channel activity 6 0.30 −3.50 −1.46
GO cellular component
 GO:0031012 Extracellular matrix 98 4.93 −13.46 −10.17
 GO:0016324 Apical plasma membrane 68 3.42 −11.60 −8.79
 GO:0044420 Extracellular matrix component 17 0.86 −6.08 −3.57
 GO:0016323 Basolateral plasma membrane 41 2.06 −5.91 −3.52
 GO:0031253 Cell projection membrane 56 2.82 −5.90 −3.52
 GO:0005604 Basement membrane 23 1.16 −5.55 −3.21
 GO:0031526 Brush border membrane 16 0.81 −5.25 −2.97
 GO:0031091 Platelet alpha granule 21 1.06 −4.93 −2.72
 GO:0030684 Pre-ribosome 19 0.96 −4.87 −2.70
 GO:0005667 Transcription factor complex 53 2.67 −4.60 −2.46
 GO:0070161 Anchoring junction 71 3.57 −3.64 −1.68
 GO:0044452 Nucleolar part 29 1.46 −3.61 −1.67
 GO:0005911 Cell-cell junction 53 2.67 −3.49 −1.60
 GO:0005773 Vacuole 93 4.68 −3.40 −1.56
 GO:0005777 Peroxisome 24 1.21 −3.40 −1.56
 GO:0034358 Plasma lipoprotein particle 10 0.50 −3.32 −1.52
 GO:0000940 Condensed chromosome outer kinetochore 6 0.30 −3.29 −1.52
 GO:0071438 Invadopodium membrane 4 0.20 −3.22 −1.48
 GO:0048471 Perinuclear region of cytoplasm 85 4.28 −3.20 −1.47
 GO:0005593 FACIT collagen trimer 4 0.20 −2.88 −1.25
KEGG pathway
 hsa04974 Protein digestion and absorption 23 1.16 −6.16 −3.46
 hsa04060 Cytokine-cytokine receptor interaction 45 2.26 −5.38 −2.98
 hsa00830 Retinol metabolism 17 0.86 −4.86 −2.64
 hsa04510 Focal adhesion 34 1.71 −4.45 −2.36
 hsa04918 Thyroid hormone synthesis 17 0.86 −4.08 −2.08
 hsa04610 Complement and coagulation cascades 17 0.86 −3.71 −1.85
 hsa04310 Wnt signaling pathway 24 1.21 −3.21 −1.49
 hsa03320 PPAR signaling pathway 15 0.75 −3.18 −1.49
 hsa05323 Rheumatoid arthritis 17 0.86 −3.02 −1.36
 hsa05146 Amoebiasis 17 0.86 −2.70 −1.27
 hsa04540 Gap junction 16 0.81 −2.69 −1.27
 hsa00471 D-Glutamine and D-glutamate metabolism 3 0.15 −2.68 −1.27
 hsa04978 Mineral absorption 11 0.55 −2.60 −1.21
 hsa04146 Peroxisome 15 0.75 −2.53 −1.16
 hsa04621 NOD-like receptor signaling pathway 25 1.26 −2.49 −1.14
 hsa04390 Hippo signaling pathway 23 1.16 −2.42 −1.13
 hsa00590 Arachidonic acid metabolism 12 0.60 −2.38 −1.13
 hsa00564 Glycerophospholipid metabolism 16 0.81 −2.35 −1.12
 hsa04976 Bile secretion 13 0.65 −2.32 −1.10
 hsa05412 Arrhythmogenic right ventricular cardiomyopathy 13 0.65 −2.26 −1.06
  1. GO, Gene Ontology. KEGG, Kyoto Encyclopedia of Genes and Genomes