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Table 3 Gene set enrichment analysis of upregulated and downregulated gene sets in the cetuximab resistant group

From: Identification of key genes involved in tumor immune cell infiltration and cetuximab resistance in colorectal cancer

Name Size Es Nes Non p value FDR q value FWER p value
Up-regulation in Resistant Group     
 HALLMARK_PEROXISOME 19 −0.36 −1.32 0.00 0.49 0.39
 HALLMARK_UV_RESPONSE_UP 24 −0.17 −1.00 0.38 1.00 1.00
 HALLMARK_MYOGENESIS 38 −0.48 −0.93 0.79 1.00 1.00
 HALLMARK_KRAS_SIGNALING_DN 27 −0.24 −0.92 0.54 1.00 1.00
 HALLMARK_ADIPOGENESIS 24 −0.17 −0.80 0.51 1.00 1.00
  HALLMARK_INTERFERON_GAMMA_RESPONSE 31 −0.21 −0.77 0.91 1.00 1.00
 HALLMARK_INTERFERON_ALPHA_RESPONSE 24 −0.28 −0.76 0.91 0.98 1.00
 HALLMARK_P53_PATHWAY 24 −0.14 −0.68 0.91 0.92 1.00
Down-regulation in Resistant Group     
 HALLMARK_COMPLEMENT 30 0.34 1.59 0.00 0.27 0.09
 HALLMARK_BILE_ACID_METABOLISM 21 0.38 1.57 0.00 0.19 0.19
 HALLMARK_IL2_STAT5_SIGNALING 31 0.38 1.50 0.00 0.16 0.25
 HALLMARK_UV_RESPONSE_DN 24 0.42 1.47 0.00 0.13 0.25
 HALLMARK_ESTROGEN_RESPONSE_EARLY 39 0.30 1.43 0.00 0.12 0.25
 HALLMARK_HYPOXIA 38 0.30 1.41 0.09 0.10 0.25
HALLMARK_APOPTOSIS 30 0.28 1.35 0.00 0.19 0.43
 HALLMARK_INFLAMMATORY_RESPONSE 29 0.44 1.29 0.00 0.25 0.56
 HALLMARK_GLYCOLYSIS 16 0.39 1.22 0.32 0.34 0.56
 HALLMARK_ESTROGEN_RESPONSE_LATE 34 0.40 1.21 0.00 0.31 0.56
 HALLMARK_XENOBIOTIC_METABOLISM 30 0.25 1.20 0.09 0.31 0.62
 HALLMARK_KRAS_SIGNALING_UP 41 0.48 1.13 0.32 0.48 0.67
 HALLMARK_TNFA_SIGNALING_VIA_NFKB 30 0.32 1.13 0.34 0.45 0.67
 HALLMARK_HEME_METABOLISM 21 0.29 1.08 0.29 0.59 0.95
 HALLMARK_APICAL_JUNCTION 26 0.28 0.99 0.44 0.88 1.00
 HALLMARK_COAGULATION 30 0.26 0.99 0.45 0.85 1.00
 HALLMARK_G2M_CHECKPOINT 19 0.40 0.98 0.54 0.82 1.00
 HALLMARK_E2F_TARGETS 21 0.37 0.97 0.69 0.79 1.00
 HALLMARK_MITOTIC_SPINDLE 15 0.29 0.95 0.66 0.80 1.00
 HALLMARK_MYC_TARGETS_V1 21 0.37 0.93 0.79 0.80 1.00
 HALLMARK_OXIDATIVE_PHOSPHORYLATION 17 0.32 0.91 0.82 0.83 1.00
 HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 44 0.29 0.91 0.59 0.80 1.00
 HALLMARK_IL6_JAK_STAT3_SIGNALING 16 0.27 0.87 0.53 0.84 1.00
 HALLMARK_ALLOGRAFT_REJECTION 22 0.23 0.81 0.75 0.89 1.00
 HALLMARK_MTORC1_SIGNALING 19 0.19 0.67 0.91 0.96 1.00
 HALLMARK_FATTY_ACID_METABOLISM 31 0.14 0.61 0.91 0.95 1.00