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Table 4 Gene set variation analysis of upregulated and downregulated gene sets in the cetuximab resistant group

From: Identification of key genes involved in tumor immune cell infiltration and cetuximab resistance in colorectal cancer

HALLMARK GENE SETS Log [FC] p value Adjustive p value
HALLMARK_MYOGENESIS 1.058 2.34E−05 3.89E−04
HALLMARK_INTERFERON_ALPHA_RESPONSE 1.115 3.21E−05 3.89E−04
HALLMARK_MYC_TARGETS_V1 −1.096 3.89E−05 3.89E−04
HALLMARK_MYC_TARGETS_V2 −1.134 2.88E−05 3.89E−04
HALLMARK_ANGIOGENESIS 1.229 1.43E−05 3.89E−04
HALLMARK_TGF_BETA_SIGNALING 1.078 9.87E−05 6.17E−04
HALLMARK_INTERFERON_GAMMA_RESPONSE 0.909 9.74E−05 6.17E−04
HALLMARK_UNFOLDED_PROTEIN_RESPONSE −0.978 7.86E−05 6.17E−04
HALLMARK_E2F_TARGETS −0.915 2.91E−04 1.45E−03
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION 0.741 2.72E−04 1.45E−03
HALLMARK_APICAL_JUNCTION 0.820 3.21E−04 1.46E−03
HALLMARK_G2M_CHECKPOINT −0.926 7.41E−04 3.09E−03
HALLMARK_APOPTOSIS 0.574 1.13E−03 4.13E−03
HALLMARK_HEME_METABOLISM 0.610 1.16E−03 4.13E−03
HALLMARK_KRAS_SIGNALING_UP −0.622 1.24E−03 4.13E−03
HALLMARK_ESTROGEN_RESPONSE_EARLY 0.572 1.41E−03 4.16E−03
HALLMARK_PEROXISOME 0.676 1.38E−03 4.16E−03
HALLMARK_UV_RESPONSE_DN 0.624 1.95E−03 5.42E−03
HALLMARK_HEDGEHOG_SIGNALING 0.742 1.96E−02 4.97E−02
HALLMARK_OXIDATIVE_PHOSPHORYLATION −0.599 2.09E−02 4.97E−02
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY 0.706 2.03E−02 4.97E−02