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Table 4 Gene set variation analysis of upregulated and downregulated gene sets in the cetuximab resistant group

From: Identification of key genes involved in tumor immune cell infiltration and cetuximab resistance in colorectal cancer

HALLMARK GENE SETS

Log [FC]

p value

Adjustive p value

HALLMARK_MYOGENESIS

1.058

2.34E−05

3.89E−04

HALLMARK_INTERFERON_ALPHA_RESPONSE

1.115

3.21E−05

3.89E−04

HALLMARK_MYC_TARGETS_V1

−1.096

3.89E−05

3.89E−04

HALLMARK_MYC_TARGETS_V2

−1.134

2.88E−05

3.89E−04

HALLMARK_ANGIOGENESIS

1.229

1.43E−05

3.89E−04

HALLMARK_TGF_BETA_SIGNALING

1.078

9.87E−05

6.17E−04

HALLMARK_INTERFERON_GAMMA_RESPONSE

0.909

9.74E−05

6.17E−04

HALLMARK_UNFOLDED_PROTEIN_RESPONSE

−0.978

7.86E−05

6.17E−04

HALLMARK_E2F_TARGETS

−0.915

2.91E−04

1.45E−03

HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

0.741

2.72E−04

1.45E−03

HALLMARK_APICAL_JUNCTION

0.820

3.21E−04

1.46E−03

HALLMARK_G2M_CHECKPOINT

−0.926

7.41E−04

3.09E−03

HALLMARK_APOPTOSIS

0.574

1.13E−03

4.13E−03

HALLMARK_HEME_METABOLISM

0.610

1.16E−03

4.13E−03

HALLMARK_KRAS_SIGNALING_UP

−0.622

1.24E−03

4.13E−03

HALLMARK_ESTROGEN_RESPONSE_EARLY

0.572

1.41E−03

4.16E−03

HALLMARK_PEROXISOME

0.676

1.38E−03

4.16E−03

HALLMARK_UV_RESPONSE_DN

0.624

1.95E−03

5.42E−03

HALLMARK_HEDGEHOG_SIGNALING

0.742

1.96E−02

4.97E−02

HALLMARK_OXIDATIVE_PHOSPHORYLATION

−0.599

2.09E−02

4.97E−02

HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY

0.706

2.03E−02

4.97E−02