Identification of key genes involved in tumor immune cell infiltration and cetuximab resistance in colorectal cancer

Table 4 Gene set variation analysis of upregulated and downregulated gene sets in the cetuximab resistant group

HALLMARK GENE SETS	Log [FC]	p value	Adjustive p value
HALLMARK_MYOGENESIS	1.058	2.34E−05	3.89E−04
HALLMARK_INTERFERON_ALPHA_RESPONSE	1.115	3.21E−05	3.89E−04
HALLMARK_MYC_TARGETS_V1	−1.096	3.89E−05	3.89E−04
HALLMARK_MYC_TARGETS_V2	−1.134	2.88E−05	3.89E−04
HALLMARK_ANGIOGENESIS	1.229	1.43E−05	3.89E−04
HALLMARK_TGF_BETA_SIGNALING	1.078	9.87E−05	6.17E−04
HALLMARK_INTERFERON_GAMMA_RESPONSE	0.909	9.74E−05	6.17E−04
HALLMARK_UNFOLDED_PROTEIN_RESPONSE	−0.978	7.86E−05	6.17E−04
HALLMARK_E2F_TARGETS	−0.915	2.91E−04	1.45E−03
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	0.741	2.72E−04	1.45E−03
HALLMARK_APICAL_JUNCTION	0.820	3.21E−04	1.46E−03
HALLMARK_G2M_CHECKPOINT	−0.926	7.41E−04	3.09E−03
HALLMARK_APOPTOSIS	0.574	1.13E−03	4.13E−03
HALLMARK_HEME_METABOLISM	0.610	1.16E−03	4.13E−03
HALLMARK_KRAS_SIGNALING_UP	−0.622	1.24E−03	4.13E−03
HALLMARK_ESTROGEN_RESPONSE_EARLY	0.572	1.41E−03	4.16E−03
HALLMARK_PEROXISOME	0.676	1.38E−03	4.16E−03
HALLMARK_UV_RESPONSE_DN	0.624	1.95E−03	5.42E−03
HALLMARK_HEDGEHOG_SIGNALING	0.742	1.96E−02	4.97E−02
HALLMARK_OXIDATIVE_PHOSPHORYLATION	−0.599	2.09E−02	4.97E−02
HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY	0.706	2.03E−02	4.97E−02

ISSN: 1475-2867