Identification of key genes involved in tumor immune cell infiltration and cetuximab resistance in colorectal cancer

Table 6 Spearman correlation analysis of differentially expressed genes and tumor-infiltrating immune cell markers in clinical samples

Tumor-infiltrating immune cells marks	Gene expression level
Tumor-infiltrating immune cells marks	Spearman correlation	95% CI	p value
SATB-
CD4	0.22	0.00 to 0.42	0.047
CD8	0.15	-0.07 to 0.35	0.184
CD19	0.36	0.16 to 0.54	< 0.001
CD68	0.34	0.14 to 0.52	0.002
CD4 and CD8	0.22	0.07 to 0.42	0.044
CD4, CD8, CD19, CD68	0.40	0.20 to 0.57	< 0.001
ORP-1
CD4	0.28	0.07 to 0.46	0.010
CD8	0.24	0.03 to 0.43	0.030
CD19	0.36	0.16 to 0.53	< 0.001
CD68	0.31	0.11 to 0.50	0.003
CD4 and CD8	0.29	0.08 to 0.48	0.007
CD4, CD8, CD19, CD68	0.42	0.23 to 0.58	< 0.001
MYB
CD4	0.22	0.01 to 0.42	0.040
CD8	0.20	-0.01 to 0.40	0.070
CD19	0.09	-0.13 to 0.30	0.450
CD68	0.28	0.07 to 0.47	0.009
CD4 and CD8	0.26	0.05 to 0.45	0.020
CD4, CD8, CD19, CD68	0.25	0.04 to 0.44	0.020
CDX-2
CD4	0.66	0.52 to 0.77	< 0.001
CD8	0.35	0.14 to 0.53	0.001
CD19	0.20	-0.02 to 0.40	0.070
CD68	0.23	0.01 to 0.43	0.030
CD4 and CD8	0.65	0.50 to 0.76	< 0.001
CD4, CD8, CD19, CD68	0.46	0.27 to 0.62	< 0.001

ISSN: 1475-2867