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Table 6 Spearman correlation analysis of differentially expressed genes and tumor-infiltrating immune cell markers in clinical samples

From: Identification of key genes involved in tumor immune cell infiltration and cetuximab resistance in colorectal cancer

Tumor-infiltrating immune cells marks Gene expression level
Spearman correlation 95% CI p value
SATB-
 CD4 0.22 0.00 to 0.42 0.047
 CD8 0.15 -0.07 to 0.35 0.184
 CD19 0.36 0.16 to 0.54 < 0.001
 CD68 0.34 0.14 to 0.52 0.002
 CD4 and CD8 0.22 0.07 to 0.42 0.044
 CD4, CD8, CD19, CD68 0.40 0.20 to 0.57 < 0.001
ORP-1
 CD4 0.28 0.07 to 0.46 0.010
 CD8 0.24 0.03 to 0.43 0.030
 CD19 0.36 0.16 to 0.53 < 0.001
 CD68 0.31 0.11 to 0.50 0.003
 CD4 and CD8 0.29 0.08 to 0.48 0.007
 CD4, CD8, CD19, CD68 0.42 0.23 to 0.58 < 0.001
MYB
 CD4 0.22 0.01 to 0.42 0.040
 CD8 0.20 -0.01 to 0.40 0.070
 CD19 0.09 -0.13 to 0.30 0.450
CD68 0.28 0.07 to 0.47 0.009
 CD4 and CD8 0.26 0.05 to 0.45 0.020
 CD4, CD8, CD19, CD68 0.25 0.04 to 0.44 0.020
CDX-2
 CD4 0.66 0.52 to 0.77 < 0.001
 CD8 0.35 0.14 to 0.53 0.001
 CD19 0.20 -0.02 to 0.40 0.070
 CD68 0.23 0.01 to 0.43 0.030
 CD4 and CD8 0.65 0.50 to 0.76 < 0.001
 CD4, CD8, CD19, CD68 0.46 0.27 to 0.62 < 0.001