Fig. 1
From: Mesenchymal stem cells and cancer therapy: insights into targeting the tumour vasculature
Naïve MSCs can inhibit Wnt signalling pathways through Dickkopf-related protein 1 (DKK1) released by tumor cells and subsequently downregulated c-Myc and Cyclin D2 and upregulated expression of P21CIP1 and P27KIP1, leading to tumor cells suppression. Naïve MSCs can cause apoptosis vascular endothelial cells by inhibiting angiogenesis