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Fig. 3 | Cancer Cell International

Fig. 3

From: MSCs loaded with oncolytic reovirus: migration and in vivo virus delivery potential for evaluating anti-cancer effect in tumor-bearing C57BL/6 mice

Fig. 3

The expression of BAX, LC3, and P53 in infected MSCs with reovirus in different MOIs and incubation time. a The expression of BAX increased via reovirus infection. Statistically, the significance level is obvious among MOIs in 72 h post-infection time except between MOI 5 and 1 (P-value > 0.05. b The LC3 expression in reovirus infected MSCs is increased via high MOIs. The post-infection time is an important factor that influences results (P-value < 0.05). c After infection of MSCs with reovirus, the expression of P53 increased. In both 48- and 72-h post-infection significant results among different MOIs were found, (P-value: 0.000). The Experiments were performed in triplicate and graphs were determined by GraphPad v.8.0.2 and analyzed by Tukey's post hoc test. (*: P ≤ 0.05; **: P ≤ 0.01; ***: P ≤ 0.001)

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