Table 1 Advantages and disadvantages of oncolytic reovirus (T3D) for cancer therapy
| Â | Role Mechanism of action | Advantages | Disadvantages |
|---|---|---|---|
oncolytic reovirus (T3D) | Oncolytic agent/ Direct lysis  Immune cell recruit  Immune cells priming | Systemically/locally administration [40] Targeting metastatic cancer cells [41] Poor adverse effects Well tolerable dosage Mild and asymptomatic [42] Specifically replicate in cancer cells with an activated Ras pathway and affinity to RAS mutant cancer cells but not in normal tissue [41,42,43] Selectively replicate in cancer cells [44] Selectively cytopathic to many human cancer cells [42] Priming of antitumor immunity Launch an immune response against cancer cells [45, 46] Induce apoptosis via triggering intrinsic/extrinsic pathway [42] | Immune-mediated neutralization both antibodies and immune cells [47, 48] Off-target effect [47] Delivery issues [40] |