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Table 1 Advantages and disadvantages of oncolytic reovirus (T3D) for cancer therapy

From: MSCs loaded with oncolytic reovirus: migration and in vivo virus delivery potential for evaluating anti-cancer effect in tumor-bearing C57BL/6 mice

  Role
Mechanism of action
Advantages Disadvantages
oncolytic reovirus (T3D) Oncolytic agent/ Direct lysis
 Immune cell recruit
 Immune cells priming
Systemically/locally administration [40]
Targeting metastatic cancer cells [41]
Poor adverse effects
Well tolerable dosage
Mild and asymptomatic [42]
Specifically replicate in cancer cells with an activated Ras pathway and affinity to RAS mutant cancer cells but not in normal tissue [41,42,43]
Selectively replicate in cancer cells [44]
Selectively cytopathic to many human cancer cells [42]
Priming of antitumor immunity
Launch an immune response against cancer cells [45, 46]
Induce apoptosis via triggering intrinsic/extrinsic pathway [42]
Immune-mediated neutralization both antibodies and immune cells [47, 48]
Off-target effect [47]
Delivery issues [40]