Table 2 Advantages and disadvantages of mesenchymal stem cells for cell-based therapy
Role Mechanism of action | Advantages | Disadvantages | |
|---|---|---|---|
Mesenchymal Stem Cell | Cell-Carrier Delivery Immunomodulatory | Availability; easy to isolate, growth and expand in culture [19,20,21, 25] Systematically/ locally administration [26] Resolve delivery issues of OV into tumoral and possible metastatic site: (protect the pre-loaded virus from immune-mediated neutralization and support viral replication) [19, 27,28,29,30,31] Natural capability to mobilize, migrate and homing [3, 32, 33] Inherent anti-cancer effects (suppress tumor growth) [27] Affecting the microenvironment of tumors [21, 33,34,35] Limited replicative lifespan (guarantees safety from the threat of malignant formation) [27] Inhibition of angiogenesis in tumoral zone [27] Deep infiltration in tumor ECM and overexpress CXC chemokine receptor 4, 7 (CXCR4, CXCR7) in response to a different set of chemokines in tumor area [8, 36,37,38] | Differentiation inside of the body [39] Tumor promoting abilities in some cases [27] Accumulation in the lung [26] |