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Table 2 Advantages and disadvantages of mesenchymal stem cells for cell-based therapy

From: MSCs loaded with oncolytic reovirus: migration and in vivo virus delivery potential for evaluating anti-cancer effect in tumor-bearing C57BL/6 mice

  Role
Mechanism of action
Advantages Disadvantages
Mesenchymal Stem Cell Cell-Carrier
Delivery
Immunomodulatory
Availability; easy to isolate, growth and expand in culture [19,20,21, 25]
Systematically/ locally administration [26]
Resolve delivery issues of OV into tumoral and possible metastatic site: (protect the pre-loaded virus from immune-mediated neutralization and support viral replication) [19, 27,28,29,30,31]
Natural capability to mobilize, migrate and homing [3, 32, 33]
Inherent anti-cancer effects (suppress tumor growth) [27]
Affecting the microenvironment of tumors [21, 33,34,35]
Limited replicative lifespan (guarantees safety from the threat of malignant formation) [27]
Inhibition of angiogenesis in tumoral zone [27]
Deep infiltration in tumor ECM and overexpress CXC chemokine receptor 4, 7 (CXCR4, CXCR7) in response to a different set of chemokines in tumor area [8, 36,37,38]
Differentiation inside of the body [39]
Tumor promoting abilities in some cases [27]
Accumulation in the lung [26]