Fig. 1
From: The loss of DLG2 isoform 7/8, but not isoform 2, is critical in advanced staged neuroblastoma
Domains found in DLG-encoded proteins, exon structure of DLG2 and DLG expression in NB. a The different isoforms of the DLG family with DLG1, DLG2 and DLG4 showing an isoform with L27 domain. The unique PSD93β protein, encoding just a partial L27 domain. The alpha isoforms of DLG1, DLG2 and DLG4 do not contain the L27 domains and thus have similar structures to DLG3. b The exon structure of DLG2 showing the 5 exons that make up the L27 and linker region in PSD93ζ with mutually exclusive initiation exons for PSD93α. Isoforms PSD93ε, PSD93δ and PSD93γ all have their initiation site after the common exon 2. Transcription start of DLG2 protein isoform indicated at the top, and protein domains at the bottom. c Gene expression of the various DLG family members showing prognosis for 586 patients from the online microarray data with the NB patient dataset (GSE49710) obtained from the R2 Genomics Analysis and Visualization Platform (http://r2.amc.nl). Kaplan–Meier diagrams with a median cut-off showing event free survival with high (blue) vs low (red) expression of (d) DLG1, (e) DLG2 and (f) DLG4. The expression data are presented as centered log2 fold change and plotted as mean ± SD. ***p < 0.001