Fig. 8

Simulations of treatment corresponding to the rotation protocols. The top panel is a violin plot showing the probability densities of WT\(_{1/2}\) values from the simulations (Y-axis: WT\(_{1/2}\), X-axis: probability densities for each protocol). The horizontal lines show minimum, median and maximum values. The bottom panel shows the median WT\(_{1/2}\). Higher WT\(_{1/2}\) values implicate that the tumour is sensitive to the treatment for a longer time. The figure was obtained by simulations of the mutational landscape using the wollsey stochastic evolution simulator [6]