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Table 2 Fold-IC50 values for FLT3 mutations relative to FLT3-ITD

From: Combating drug resistance in acute myeloid leukaemia by drug rotations: the effects of quizartinib and pexidartinib

Mutation

Fold IC50 quizartinib

Fold IC50 pexidartinib

None

1

1

F691L

329

3

D835A

10

18

D835E

6

9

D835F

1474

415

D835G

10

13

D835H

45

40

D835I

718

1937

D835N

7

10

D835V

563

320

D835Y

183

206

D835Del

320

121

D839G

6

27

Y842C

106

48

Y842H

58

49

  1. This is the data used in simulations of the cells. The values were calculated based on Refs. [12, 35, 36]
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Cancer Cell International

ISSN: 1475-2867

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