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Table 2 Fold-IC50 values for FLT3 mutations relative to FLT3-ITD

From: Combating drug resistance in acute myeloid leukaemia by drug rotations: the effects of quizartinib and pexidartinib

Mutation Fold IC50 quizartinib Fold IC50 pexidartinib
None 1 1
F691L 329 3
D835A 10 18
D835E 6 9
D835F 1474 415
D835G 10 13
D835H 45 40
D835I 718 1937
D835N 7 10
D835V 563 320
D835Y 183 206
D835Del 320 121
D839G 6 27
Y842C 106 48
Y842H 58 49
  1. This is the data used in simulations of the cells. The values were calculated based on Refs. [12, 35, 36]