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Fig. 3 | Cancer Cell International

Fig. 3

From: SOCS6 promotes radiosensitivity and decreases cancer cell stemness in esophageal squamous cell carcinoma by regulating c-Kit ubiquitylation

Fig. 3

SOCS6 suppresses cell proliferation, migration and drug resistance of ESCC cells. a, b Cell proliferation assays were performed, and SOCS6 was found to inhibit cell growth (n = 5); c Eca109 and KYSE-150 cells were treated with cisplatin (1.25, 2.5, 5, 10 and 15 µg/mL for Eca109 cells and 1.25, 2.5, 5, 10 and 20 µg/mL for KYSE-150 cells) for 24 h and 48 h respectively (n = 5). Cisplatin sensitivity increased significantly with overexpression of SOCS6; (d) Cisplatin sensitivity decreased with knockdown of SOCS6 (n = 5). e, f The migration ability of Eca109 and KYSE-150 cells with SOCS6 overexpression was evaluated by transwell assays, which indicated that SOCS6 decreased cell migration ability (n = 3). g, h Knockdown of SOCS6 did not impact cell migration ability (n = 3). The data are presented as mean ± SD, *P < 0.05, **P < 0.01 and ***P < 0.001

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