From: The importance of CDC27 in cancer: molecular pathology and clinical aspects
dbSNP rs number | cDNA/protein (NM_001114091) | Exon/intron position; TPR domain | Effect/Neoplasm | CGI classification | References |
---|---|---|---|---|---|
rs79201963 | c.1549G>A;p.E517K | Exon12;TPR6 | Tumorigenic roles in calcifying fibrous tumor of the pleura | Tier 1 | [54] |
rs77095606 | c.644T>G;p.L215W | Exon6 | Passenger | ||
rs199899451 | c.505A>T;p.K169* | Exon6 | Tier 1 | ||
rs796969472 | c.1801C>G;p.Q601E | Exon14;TPR8 | NA | ||
rs775321736 | c.1795G>A;p.A599T | Exon14;TPR8 | Tier 1 | ||
rs796538886 | c.1459T>G;p.C487G | Exon12;TPR5 | Tier 1 | ||
rs7350889 | c.794G>A;p.G265D | Exon7 | Possible driver in a subset of sporadic vestibular schwannoma | Passenger | [53] |
rs62077279 | c.17A>G;p.E6G | Exon1;TPR1 | Potential biomarker for Osteosarcoma | Tier 1 | [56] |
rs74628496 | c.705T>C;p.I235I | Exon7 | Tumorigenesis/molecular pathogenesis of colon cancer | NA | [59] |
rs747953129 | 501A>G;p.T167T | Exon6 | Polymorphism | ||
rs77467652 | c.449C>A; p.S150Y | Exon4 | Passenger | ||
rs193061947 | c.704T>C; p.I235T | Exon7 | Tumorigenesis/potential therapeutic targets in lung adenocarcinoma | NA | [60] |
rs200611688 | c.818C>G;p.A273G | Exon7 | Polymorphism | ||
– | c.1034G>T;p.S345I | Exon9 | Unknown roles in Adrenocortical carcinoma | Passenger | [66] |
rs200940073 | c.1541C>T;p.A514V | Exon12;TPR6 | Tier 1 | ||
rs202052665 | c.1504T>C;p.Y502H | Exon12 | Passenger |