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Table 3 The somatic variants in CDC27 associated to cancer progression

From: The importance of CDC27 in cancer: molecular pathology and clinical aspects

dbSNP rs number

cDNA/protein (NM_001114091)

Exon/intron position; TPR domain

Effect/Neoplasm

CGI classification

References

rs79201963

c.1549G>A;p.E517K

Exon12;TPR6

Tumorigenic roles in calcifying fibrous tumor of the pleura

Tier 1

[54]

rs77095606

c.644T>G;p.L215W

Exon6

Passenger

rs199899451

c.505A>T;p.K169*

Exon6

Tier 1

rs796969472

c.1801C>G;p.Q601E

Exon14;TPR8

NA

rs775321736

c.1795G>A;p.A599T

Exon14;TPR8

Tier 1

rs796538886

c.1459T>G;p.C487G

Exon12;TPR5

Tier 1

rs7350889

c.794G>A;p.G265D

Exon7

Possible driver in a subset of sporadic vestibular schwannoma

Passenger

[53]

rs62077279

c.17A>G;p.E6G

Exon1;TPR1

Potential biomarker for Osteosarcoma

Tier 1

[56]

rs74628496

c.705T>C;p.I235I

Exon7

Tumorigenesis/molecular pathogenesis of colon cancer

NA

[59]

rs747953129

501A>G;p.T167T

Exon6

Polymorphism

rs77467652

c.449C>A; p.S150Y

Exon4

Passenger

rs193061947

c.704T>C; p.I235T

Exon7

Tumorigenesis/potential therapeutic targets in lung adenocarcinoma

NA

[60]

rs200611688

c.818C>G;p.A273G

Exon7

Polymorphism

–

c.1034G>T;p.S345I

Exon9

Unknown roles in Adrenocortical carcinoma

Passenger

[66]

rs200940073

c.1541C>T;p.A514V

Exon12;TPR6

Tier 1

rs202052665

c.1504T>C;p.Y502H

Exon12

Passenger

  1. NA not available, VUS Variant of Uncertain Significance