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Fig. 8 | Cancer Cell International

Fig. 8

From: Identification of four key prognostic genes and three potential drugs in human papillomavirus negative head and neck squamous cell carcinoma

Fig. 8

GSEA of computational gene sets, oncogenic gene sets and curated gene sets in TCGA samples with high expression vs low expression of AREG, CAV1 and STAG3. ad The upregulation of AREG was associated with module 159 (translation regulation), the KRAS dependency signature, GTSE1 in G2/M progression after the G2 checkpoint, and genes upregulated in SCC12B2 cells (squamous cell carcinoma) by UV-B irradiation. eh The upregulation of CAV1 was associated with module 159 (translation regulation), the KRAS dependency signature, regulation of RAS by GAPs, and oncogenesis by MET. il The downregulation of STAG3 was associated with module 159 (translation regulation), RB and P107 downregulation, poor differentiation and metastasis of HNSCC

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