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Table 2 Ten most significant small molecule drugs

From: Identification of four key prognostic genes and three potential drugs in human papillomavirus negative head and neck squamous cell carcinoma

Name PubChem CID Target MOA Score
SB-216763 176,158 GSK3B, CCNA2, CDK2, GSK3A Glycogen synthase kinase inhibitor − 98.08
ABT-751 3,035,714 TUBB Tubulin inhibitor − 97.94
Vinorelbine 73,707,424 TUBB Tubulin inhibitor − 97.78
Etacrynic-acid 3278 SLC12A1, ATP1A1, SLC12A2 Sodium/potassium/chloride transporter inhibitor − 97.1
Entinostat 4261 HDAC1, HDAC2, HDAC3, HDAC9 HDAC inhibitor − 95.33
PTB1 24,857,885 PTPN1 AMPK activator 99.08
Zonisamide 5734 CA1, CA12, CA7, SCN1A, CA10, CA11, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA8, CA9, CACNA1G, CACNA1H, CACNA1I, MAOA, MAOB, SCN11A, SCN1B, SCN2A, SCN2B, SCN3A, SCN3B, SCN4A, SCN4B, SCN5A, SCN9A Sodium channel blocker, T-type calcium channel blocker 95.23
NVP-AUY922 10,096,043 HSP90AA1, HSP90AA2, HSP90AB1 HSP inhibitor 93.61
PP-2 4878 SRC, LCK, ABL1, LYN, RIPK2 SRC inhibitor 93.03
Fostamatinib 11,213,558 SYK, FLT3, RET SYK inhibitor 92.89