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Table 1 Expression, clinical significance, and biological functions of VIRMA in various cancers

From: Role of m6A methyltransferase component VIRMA in multiple human cancers (Review)

Cancer type Expression Clinical significance Biological functions Methodology In vivo or in vitro References
Breast cancer Upregulated (46 pairs) Oncogene Proliferation, metastasis, tumorigenesis mRNA high-throughput sequencing; RIP-seq; m6A dot blot assay; mRNA FISH; mRNA stability analysis; In vivo and in vitro [20]
Upregulated (1109 BRC tissues and 113 normal breast tissues from TCGA; TMA containing 20 BRC specimens and 20 normal breast tissue specimens) TMA cohorts; Immunohistochemical staining; Immunofluorescence assay [42]
Upregulated (~ 7400 samples representing 11 cancer types) [41]
Liver cancer Upregulated (70 pairs) Oncogene Cell proliferation, tumor growth and metastasis, cell apoptosis resistance RNA-seq; RIP-seq; MeRIP-seq In vivo and in vitro [29]
Upregulated (371 liver cancer tissues and 50 normal liver tissues from TCGA) Oncogene Cell proliferation, cell migration and invasion MeRIP-PCR In vitro [43]
Upregulated (374 HCC and 50 normal tissues from TCGA; 243 HCC and 202 normal tissues from ICGC) Oncogene [45]
Gastric cancer Upregulated (20 pairs) Oncogene Proliferation Dual‐luciferase reporter gene assay; RIP; RNA-seq In vivo and in vitro [30]
Upregulated (~ 7400 samples representing 11 cancer types) [41]
Kidney cancer Upregulated Oncogene [44]
[41]
Kidney renal papillary cell carcinoma Downregulated (289 kidney renal papillary cell carcinoma and 32 normal kidney samples from the TCGA database) [49]
Bladder cancer Oncogene [44]
No difference (408 bladder cancer patients from TCGA) Oncogene [48]
Prostate cancer Upregulated (TCGA + GTEx, 492 prostate adenocarcinoma and 152 adjacent normal specimens) Oncogene Proliferation, metastasis RNA methylation quantification; immunofluorescence Analysis; RT2 lncRNA PCR Array Human Cancer PathwayFinder; N6-methyladenosine immunoprecipitation In vitro [58]
Upregulated [44]
Testicular cancer Upregulated Oncogene qRT-PCR; Immunohistochemistry In vitro [32]
Upregulated Oncogene [44]
Head and neck squamous cell carcinoma TCGA [31]
Osteosarcoma Upregulated Oncogene Proliferation, invasion, and migration Tissue microarray (TMA) construction and immunohistochemistry (IHC); dual luciferase reporter gene assay In vivo and in vitro [50]
Lung squamous cell carcinoma Upregulated (~ 7400 samples representing 11 cancer types) [41]
Colon adenocarcinoma Upregulated (~ 7400 samples representing 11 cancer types) [41]
Rectum adenocarcinoma Upregulated (~ 7400 samples representing 11 cancer types) [41]
Lung adenocarcinoma Upregulated (~ 7400 samples representing 11 cancer types) [41]
Cholangiocarcinoma Upregulated (~ 7400 samples representing 11 cancer types) [41]
Uterine corpus endometrial carcinoma Downregulated (~ 7400 samples representing 11 cancer types) [41]
Thyroid carcinoma Downregulated (~ 7400 samples representing 11 cancer types) [41]
papillary thyroid carcinoma Downregulated (499 tumor tissues and 58 normal thyroid carcinoma) Tumor suppressor gene [52]
Ovarian cancer Downregulated (TCGA, 370 ovarian cancer tissues and 88 normal tissues) [51]
  1. TCGA: http://cancergenome.nih.gov/
  2. ICGC: https://dcc.icgc.org/releases/current/Projects/LIRI-JP
  3. GTEx: https://gtexportal.org/