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Table 1 All of the miRNAs associated with Doxorubicin resistance in BC

From: MicroRNAs as the critical regulators of Doxorubicin resistance in breast tumor cells

Study Year Gene Country Target samples Results
Developmental factors and signaling pathways
Wu [24] 2019 miR-140-5p China WNT1 MCF-7, MDA-MB-231 cell lines Increased Dox sensitivity
Cheng [31] 2019 miR-137 China FSTL1 87 patients
HCC38, MDA-MB-231, and MDA-MB-468 cell lines
Increased Dox sensitivity
Xiong [36] 2018 miR-613 China DAAM1 123 patients
MDA-MB-231, MCF-7, HEK-293 T, and SUM1315 cell lines
Increased Dox sensitivity
Li [42] 2012 miR-34a China NOTCH1 38 patients
MCF-7 cell line
Increased Dox sensitivity
Hu [47] 2016 miR-760 China NANOG and SNAIL MCF-7, MDA-MB-231 cell lines Increased Dox sensitivity
Kim [55] 2016 miR-34a Korea PRKD1 MCF-7, MDA-MB-231 cell lines Increased Dox sensitivity
PI3K/AKT and MAPK signaling pathways
Shen [57] 2016 miR-29a China PTEN MCF-7 cell line Increased Dox resistance
Hu [58] 2016 miR-205 China VEGFA and FGF2 30 patients
MCF-7 cell line
Increased Dox sensitivity
Liu [59] 2019 miR-202-5p China PI3K and AKT 62 patients
MCF-10A and MCF-7 cell lines
Increased Dox resistance
Kopp [70] 2012 miR-200c Germany TRKB and BMI1 MDA-MB-436 and BT474 cell lines Increased Dox sensitivity
Xie [73] 2018 miR-132 and miR-212 China PTEN 53 patients
MCF-7 cell line
Increased Dox resistance
Shen [74] 2017 miR-222 China PTEN MCF-7 cell line Increased Dox resistance
Wang [75] 2011 miR-21 China PTEN MCF-7 cell line Increased Dox resistance
Chu [76] 2017 miR-93 China PTEN 16 patients
MCF-7 cell line
Increased Dox resistance
Chen [77] 2013 miR-200c China ZEB1 MCF-7 cell line Increased Dox sensitivity
Fang [84] 2014 miR-30c China YWHAZ MCF-7, MDA-MB-231 cell lines Increased Dox sensitivity
Du [86] 2019 miR-137 China DUSP4 MCF-7, HCC1937, and MDA-MB-468 cell lines Increased Dox sensitivity
Mi [88] 2018 miR-381 China FYN MCF-7, MDA-MB-231 cell lines Increased Dox sensitivity
Zhao [92] 2016 miR-302 China MEKK1 MCF-7 cell line Increased Dox sensitivity
Apoptosis, cell cycle, and DNA repair
Zheng [96] 2016 miR-181b China BIM 30 patients
MCF-10A, T-47D, MCF-7, MDA-MB-231, and MDA-MB-435 cell lines
Increased Dox resistance
Dai [97] 2019 miR-222 China BIM 25 patients
MCF-7 cell line
Increased Dox sensitivity
Long [101] 2015 miR-193b China MCL1 MCF-7 cell line Increased Dox sensitivity
Hu [103] 2015 miR-218 China BIRC5 MCF-7 and CAL-51 cell lines Increased Dox sensitivity
Li [108] 2019 miR-3609 China PDL1 47 patients
HBL-100, MCF-7, MDA-MB-231, and MDA-MB-468 cell lines
Increased Dox sensitivity
Zhang [112] 2019 miR-192-5p China PPIA and BCL2 MCF-10A, MCF-7 cell lines Increased Dox sensitivity
Zhang [114] 2016 miR-214 China RFWD2 31 patients
MCF-7, MDA-MB-231, and MDA-MB-468 cell lines
Increased Dox sensitivity
Tormo [115] 2019 miR-449 Spain CDK2, E2F1, and E2F3 30 patients
MDA-MB-231, MDA-MB-468, and MCF-7 cell lines
Increased Dox sensitivity
Lu [121] 2020 miR-140 China FEN1 MCF-7 cell line Increased Dox sensitivity
Lin [124] 2019 miR-30c China REV1 and FANCF MCF-7, ZR-75–1, T-47D, MDA-MB-231, and MCF-10A cell lines Increased Dox sensitivity
Transporters
Lu [129] 2015 miR-134 China ABCC1 40 patients
MCF-7 cell line
Increased Dox sensitivity
Chang [131] 2018 miR-199a China MRP1 MCF-7 Increased Dox sensitivity
Gao [132] 2016 miR-145 China MRP1 112 patients
MCF-7, MDA-MB-231, MDA-MB-453, MDA-MB-468, and MCF-10A cell lines
Increased Dox sensitivity
Chen [135] 2012 miR-200c China MDR1 39 patients
MCF-7 and MDA-MB-231 cell lines
Increased Dox sensitivity
Kovalchuk [136] 2008 miR-451 Canada MDR1 MCF-7 cell line Increased Dox sensitivity
Hu [137] 2019 miR-124-3p China ABCC4 40 patients
MCF-7 and MCF-10A cell lines
Increased Dox sensitivity
Yuan [143] 2015 miR-133a China UCP2 MCF-7 cell line Increased Dox sensitivity
TGF-β and JAK/STAT signaling pathways
Sun [146] 2018 miR-574 China SMAD4 30 patients
MCF-7 cell line
Increased Dox resistance
Jiang [148] 2014 miR-489 China SMAD3 MCF-7 cell line Increased Dox sensitivity
Liang [150] 2019 miR-548-p China PBLD MCF-7 and MDA-MB-231 cell lines Increased Dox resistance
Liu [155] 2019 miR-124 China STAT3 and HIF1 MCF-7 cell line Increased Dox sensitivity
Enzymes and structural proteins
Han [161] 2019 miR-181c China OPN 29 patients
MCF-7 cell line
Increased Dox sensitivity
Zhang [165] 2019 miR-135b-5p China AGR2 28 patients
MCF-7 and MDA-MB-231 cell lines
Increased Dox sensitivity
Bolandghamat pour [171] 2019 miR-154 Iran NAMPT MCF-7, MCF-10A, and MDA-MB-231 cell lines Increased Dox sensitivity
Li [175] 2018 miR-770 China STMN1 MDA-MB-231, MDA-MB-468, and THP-1 cell lines Increased Dox sensitivity