Table 1 All of the miRNAs associated with Doxorubicin resistance in BC
From: MicroRNAs as the critical regulators of Doxorubicin resistance in breast tumor cells
Study | Year | Gene | Country | Target | samples | Results |
|---|---|---|---|---|---|---|
Developmental factors and signaling pathways | ||||||
Wu [24] | 2019 | miR-140-5p | China | WNT1 | MCF-7, MDA-MB-231 cell lines | Increased Dox sensitivity |
Cheng [31] | 2019 | miR-137 | China | FSTL1 | 87 patients HCC38, MDA-MB-231, and MDA-MB-468 cell lines | Increased Dox sensitivity |
Xiong [36] | 2018 | miR-613 | China | DAAM1 | 123 patients MDA-MB-231, MCF-7, HEK-293Â T, and SUM1315 cell lines | Increased Dox sensitivity |
Li [42] | 2012 | miR-34a | China | NOTCH1 | 38 patients MCF-7 cell line | Increased Dox sensitivity |
Hu [47] | 2016 | miR-760 | China | NANOG and SNAIL | MCF-7, MDA-MB-231 cell lines | Increased Dox sensitivity |
Kim [55] | 2016 | miR-34a | Korea | PRKD1 | MCF-7, MDA-MB-231 cell lines | Increased Dox sensitivity |
PI3K/AKT and MAPK signaling pathways | ||||||
Shen [57] | 2016 | miR-29a | China | PTEN | MCF-7 cell line | Increased Dox resistance |
Hu [58] | 2016 | miR-205 | China | VEGFA and FGF2 | 30 patients MCF-7 cell line | Increased Dox sensitivity |
Liu [59] | 2019 | miR-202-5p | China | PI3K and AKT | 62 patients MCF-10A and MCF-7 cell lines | Increased Dox resistance |
Kopp [70] | 2012 | miR-200c | Germany | TRKB and BMI1 | MDA-MB-436 and BT474 cell lines | Increased Dox sensitivity |
Xie [73] | 2018 | miR-132 and miR-212 | China | PTEN | 53 patients MCF-7 cell line | Increased Dox resistance |
Shen [74] | 2017 | miR-222 | China | PTEN | MCF-7 cell line | Increased Dox resistance |
Wang [75] | 2011 | miR-21 | China | PTEN | MCF-7 cell line | Increased Dox resistance |
Chu [76] | 2017 | miR-93 | China | PTEN | 16 patients MCF-7 cell line | Increased Dox resistance |
Chen [77] | 2013 | miR-200c | China | ZEB1 | MCF-7 cell line | Increased Dox sensitivity |
Fang [84] | 2014 | miR-30c | China | YWHAZ | MCF-7, MDA-MB-231 cell lines | Increased Dox sensitivity |
Du [86] | 2019 | miR-137 | China | DUSP4 | MCF-7, HCC1937, and MDA-MB-468 cell lines | Increased Dox sensitivity |
Mi [88] | 2018 | miR-381 | China | FYN | MCF-7, MDA-MB-231 cell lines | Increased Dox sensitivity |
Zhao [92] | 2016 | miR-302 | China | MEKK1 | MCF-7 cell line | Increased Dox sensitivity |
Apoptosis, cell cycle, and DNA repair | ||||||
Zheng [96] | 2016 | miR-181b | China | BIM | 30 patients MCF-10A, T-47D, MCF-7, MDA-MB-231, and MDA-MB-435 cell lines | Increased Dox resistance |
Dai [97] | 2019 | miR-222 | China | BIM | 25 patients MCF-7 cell line | Increased Dox sensitivity |
Long [101] | 2015 | miR-193b | China | MCL1 | MCF-7 cell line | Increased Dox sensitivity |
Hu [103] | 2015 | miR-218 | China | BIRC5 | MCF-7 and CAL-51 cell lines | Increased Dox sensitivity |
Li [108] | 2019 | miR-3609 | China | PDL1 | 47 patients HBL-100, MCF-7, MDA-MB-231, and MDA-MB-468 cell lines | Increased Dox sensitivity |
Zhang [112] | 2019 | miR-192-5p | China | PPIA and BCL2 | MCF-10A, MCF-7 cell lines | Increased Dox sensitivity |
Zhang [114] | 2016 | miR-214 | China | RFWD2 | 31 patients MCF-7, MDA-MB-231, and MDA-MB-468 cell lines | Increased Dox sensitivity |
Tormo [115] | 2019 | miR-449 | Spain | CDK2, E2F1, and E2F3 | 30 patients MDA-MB-231, MDA-MB-468, and MCF-7 cell lines | Increased Dox sensitivity |
Lu [121] | 2020 | miR-140 | China | FEN1 | MCF-7 cell line | Increased Dox sensitivity |
Lin [124] | 2019 | miR-30c | China | REV1 and FANCF | MCF-7, ZR-75–1, T-47D, MDA-MB-231, and MCF-10A cell lines | Increased Dox sensitivity |
Transporters | ||||||
Lu [129] | 2015 | miR-134 | China | ABCC1 | 40 patients MCF-7 cell line | Increased Dox sensitivity |
Chang [131] | 2018 | miR-199a | China | MRP1 | MCF-7 | Increased Dox sensitivity |
Gao [132] | 2016 | miR-145 | China | MRP1 | 112 patients MCF-7, MDA-MB-231, MDA-MB-453, MDA-MB-468, and MCF-10A cell lines | Increased Dox sensitivity |
Chen [135] | 2012 | miR-200c | China | MDR1 | 39 patients MCF-7 and MDA-MB-231 cell lines | Increased Dox sensitivity |
Kovalchuk [136] | 2008 | miR-451 | Canada | MDR1 | MCF-7 cell line | Increased Dox sensitivity |
Hu [137] | 2019 | miR-124-3p | China | ABCC4 | 40 patients MCF-7 and MCF-10A cell lines | Increased Dox sensitivity |
Yuan [143] | 2015 | miR-133a | China | UCP2 | MCF-7 cell line | Increased Dox sensitivity |
TGF-β and JAK/STAT signaling pathways | ||||||
Sun [146] | 2018 | miR-574 | China | SMAD4 | 30 patients MCF-7 cell line | Increased Dox resistance |
Jiang [148] | 2014 | miR-489 | China | SMAD3 | MCF-7 cell line | Increased Dox sensitivity |
Liang [150] | 2019 | miR-548-p | China | PBLD | MCF-7 and MDA-MB-231 cell lines | Increased Dox resistance |
Liu [155] | 2019 | miR-124 | China | STAT3 and HIF1 | MCF-7 cell line | Increased Dox sensitivity |
Enzymes and structural proteins | ||||||
Han [161] | 2019 | miR-181c | China | OPN | 29 patients MCF-7 cell line | Increased Dox sensitivity |
Zhang [165] | 2019 | miR-135b-5p | China | AGR2 | 28 patients MCF-7 and MDA-MB-231 cell lines | Increased Dox sensitivity |
Bolandghamat pour [171] | 2019 | miR-154 | Iran | NAMPT | MCF-7, MCF-10A, and MDA-MB-231 cell lines | Increased Dox sensitivity |
Li [175] | 2018 | miR-770 | China | STMN1 | MDA-MB-231, MDA-MB-468, and THP-1 cell lines | Increased Dox sensitivity |