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Fig. 1 | Cancer Cell International

Fig. 1

From: miR-320a/SP1 negative reciprocal interaction contributes to cell growth and invasion in colorectal cancer

Fig. 1

miR-320a is aberrantly downregulated in CRC tissues and cell lines. a In colon cancer (COAD) and rectal cancer (READ), the expression of miR-320a was significantly decreased in CRC tissues. The CRC miR-320a expression data was extracted from The Cancer Genome Atlas (TCGA) and analyzed using OncomiR online software. b Wilcoxon paired test showed downregulation of miR-320a (P = 0.0034) and c upregulation of SP1 (P = 0.027) in tissues from a cohort of 12 primary CRCs compared to their matched normal epithelial controls. d A commonly exhibited pattern of decreased miR-320a expression in seven CRC cell lines compared with the FHC normal human colonic epithelial cell line

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