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Fig. 4 | Cancer Cell International

Fig. 4

From: miR-320a/SP1 negative reciprocal interaction contributes to cell growth and invasion in colorectal cancer

Fig. 4

miR-320a inhibited CRC cell growth, colony formation, and invasion by directly targeting SP1. A rescue experiment was performed to determine if miR-320a exhibits tumor suppressive features by targeting SP1. a Immunoblotting assays showed that downregulation of SP1 expression induced by ectopic miR-320a was abrogated by transfection of an SP1-expression vector into SW480 and SW620 cells. Normalized intensity of each immunoblot was analyzed and is annotated below the stripes. Consequently, restoration of SP1 partly reversed the inhibitory influences of miR-320a on cell growth (b) (*P < 0.05; **P < 0.01), colony formation (c) and cell invasion (d)

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