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Fig. 2 | Cancer Cell International

Fig. 2

From: LINC00514 upregulates CCDC71L to promote cell proliferation, migration and invasion in triple‐negative breast cancer by sponging miR-6504-5p and miR-3139

Fig. 2

LINC00514 knockdown played inhibitory role in TNBC cell growth and migration. a Transfection efficiency of sh-LINC00514 in MDA-MB-468 and HCC1937 cells was evaluated by RT-qPCR. b, c Colony formation assay and EdU assay were carried out to assess cell (MDA-MB-468, HCC1937) proliferative ability with LINC00514 silencing. d Apoptosis of sh-LINC00514 transfected TNBC cells was detected by flow cytometry analysis. e, f Impact of LINC00514 deficiency in levels of apoptosis-associated proteins was evaluated with western blot. g, h Wound healing assay verified migratory ability of LINC00514-depleted TNBC cells. i Transwell assay was performed detecting cell invasive ability under LINC00514 knockdown. **p < 0.01, ***p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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