Fig. 1

a, d, f Boxplots displaying the expression of GTF2E2 in lung adenocarcinoma and adjacent normal tissue based on the RNA sequencing or microarray data from TCGA (a), GEO (b), and our institution (f). Within each group, the scattered dots represent the value of each individual patient. The lines in the boxes represent the median value. The bottom and top of the boxes are the 25th and 75th percentiles (interquartile range). The whiskers encompass 1.5 times the interquartile range. The statistical difference of two scores was compared through the Wilcoxon test. b, e Boxplots displaying the expression of GTF2E2 in early and advanced lung adenocarcinoma tissue based on the RNA sequencing data from TCGA (b), and GEO (e). c Kaplan–Meier curves of overall survival stratified by GTF2E2 level in TCGA. g, i Quantitative RT-PCR and single-cell sequencing analyses of the expression of GTF2E2 in surgical resected lung adenocarcinoma and adjacent normal tissue. h Representative IHC staining images indicating the upregulation of GTF2E2 in lung adenocarcinoma. **p < 0.01; ***p < 0.001