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Fig. 5 | Cancer Cell International

Fig. 5

From: Inhibition of KIF20A by transcription factor IRF6 affects the progression of renal clear cell carcinoma

Fig. 5

IRF6 directly binds to the KIF20A promoter to regulate KIF20A expression. a JASPAR database predicts binding sites between IRF6 and KIF20A. b Correlation between IRF6 and KIF20A expression in ccRCC. c The correlation between IRF6 and KIF20A (the qPCR expression). d RT-qPCR detected the expression of KIF20A. e Western blot detected the expression of KIF20A. **P < 0.01, ***P < 0.001 vs shRNA-NC. ###P < 0.001 vs Oe-NC. f Luciferase was used to detect the transcriptional activity of KIF20A promoter mutant in ccRCC cells. *P < 0.05 vs KIF20A-WT + Oe-IRF6. g ChIP verified that IRF6 binds to the KIF20A promoter. ***P < 0.001 vs Input. ###P < 0.001 vs IgG

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Cancer Cell International

ISSN: 1475-2867

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