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Table 1 Correlations between SHMT2 and clinicopathological characteristics of oral squamous cell carcinoma in TCGA database (n = 96)

From: Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation

Characteristics SHMT2 expression
High Low p value
Anatomic site
 Alveolar Ridge 5 5 0.215
 Buccal Mucosa 6 3  
 Floor of mouth 20 9  
 Hard palate 0 2  
 Oral Cavity 11 7  
 Tongue 12 16  
Age (years)
 < 61 24 28 0.03*
 ≥ 61 30 14
Gender
 Male 36 30 0.618
 Female 18 12
Alcohol history
 Yes 32 36 0.005**
 No 22 6
Tobacco smoking history
 Yes 36 30 0.618
 No 18 12
pT stage
 T1–2 13 20 0.016*
 T3–4 41 22
pN stage
 N 17 20 0.039*
 N+ 37 22
pM stage
 M 39 34 0.320
 M+ 15 8
Clinical stage
 I–II 8 17 0.004**
 III–IV 46 25
Histologic grade
 Well 4 10 0.078
 Moderately 39 25
 Poorly 11 7
Lymph node neck dissection
 Yes 52 40 1.000
 No 2 2
Lymph vascular invasion
 Yes 20 10 0.165
 No 34 32
Perineural invasion
 Yes 26 23 0.520
 No 28 19
Close or positive margin
 Yes 22 9 0.045*
 No 32 33
Recurrence
 Yes 21 10 0.117
 No 33 32
  1. pT stage pathologic T stage, pN stage pathologic N stage, pM stage pathologic M stage
  2. *represents P < 0.05, **represents P < 0.01, ***represents P < 0.001