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Table 1 Correlations between SHMT2 and clinicopathological characteristics of oral squamous cell carcinoma in TCGA database (n = 96)

From: Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation

Characteristics

SHMT2 expression

High

Low

p value

Anatomic site

 Alveolar Ridge

5

5

0.215

 Buccal Mucosa

6

3

 

 Floor of mouth

20

9

 

 Hard palate

0

2

 

 Oral Cavity

11

7

 

 Tongue

12

16

 

Age (years)

 < 61

24

28

0.03*

 ≥ 61

30

14

Gender

 Male

36

30

0.618

 Female

18

12

Alcohol history

 Yes

32

36

0.005**

 No

22

6

Tobacco smoking history

 Yes

36

30

0.618

 No

18

12

pT stage

 T1–2

13

20

0.016*

 T3–4

41

22

pN stage

 N−

17

20

0.039*

 N+

37

22

pM stage

 M−

39

34

0.320

 M+

15

8

Clinical stage

 I–II

8

17

0.004**

 III–IV

46

25

Histologic grade

 Well

4

10

0.078

 Moderately

39

25

 Poorly

11

7

Lymph node neck dissection

 Yes

52

40

1.000

 No

2

2

Lymph vascular invasion

 Yes

20

10

0.165

 No

34

32

Perineural invasion

 Yes

26

23

0.520

 No

28

19

Close or positive margin

 Yes

22

9

0.045*

 No

32

33

Recurrence

 Yes

21

10

0.117

 No

33

32

  1. pT stage pathologic T stage, pN stage pathologic N stage, pM stage pathologic M stage
  2. *represents P < 0.05, **represents P < 0.01, ***represents P < 0.001