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Fig. 3 | Cancer Cell International

Fig. 3

From: Identification of potential plasma biomarkers in early-stage nasopharyngeal carcinoma-derived exosomes based on RNA sequencing

Fig. 3

Differential expression and enrichment analysis of exosome miRNAs. a Volcano map showing the overall differentially expressed miRNAs (DEmiRNAs) in the two groups. Each point represents a miRNA. Points in green indicate downregulated miRNAs (fold change > 2 and P < 0.05), while points in red indicate upregulated miRNAs (fold change > 2 and P < 0.05). Blue dots indicate miRNAs (fold change < 2 and P > 0.05). b Heat map analysis of DEmiRNAs. The color of the heat map indicates the relative miRNA expressions. Green indicates low expression level. Red indicates high expression level. c GO analysis for target genes of down-regulated miRNAs. The vertical axis indicates the GO name, the horizontal axis indicates the size of the fold enrichment, the dots represent the number of DEGs in this GO, and the color of the dot relates to different P-value ranges. d GO analysis for target genes of upregulated miRNAs. The vertical axis indicates the GO name. The horizontal axis indicates the size of the fold enrichment. Dots represent the number of DEGs in this GO, and the color of the point is related to different P-value ranges. e, f KEGG for target genes of down-regulated miRNAs (e) and up-regulated mi RNAs (f). The vertical axis indicates the KEGG name, the horizontal axis indicates the size of the ratio. Dots represent the number of DEGs in this KEGG, and the color of the dot is related to different P-value ranges

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