TY - JOUR AU - Dai, Li AU - Li, Mao AU - Zhang, Wei-long AU - Tang, Ya-Jie AU - Tang, Ya-ling AU - Liang, Xin-hua PY - 2021 DA - 2021/03/26 TI - Fibroblasts in cancer dormancy: foe or friend? JO - Cancer Cell International SP - 184 VL - 21 IS - 1 AB - Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which represent a predominant cell type in tumor microenvironment, play a pivotal role in determining the ultimate fate of tumor cells. This review recapitulates the pleiotropic roles of fibroblasts which are divided into normal, senescent, cancer-associated fibroblasts (CAFs) and circulation CAFs in tumor dormancy, relapse, metastasis and resistance to therapy to help the treatment of cancer metastasis. SN - 1475-2867 UR - https://doi.org/10.1186/s12935-021-01883-2 DO - 10.1186/s12935-021-01883-2 ID - Dai2021 ER -