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Fig. 5 | Cancer Cell International

Fig. 5

From: Circ_0000745 strengthens the expression of CCND1 by functioning as miR-488 sponge and interacting with HuR binding protein to facilitate the development of oral squamous cell carcinoma

Fig. 5

CCND1 was a target of miR-488. a The binding site between miR-488 and CCND1 3’UTR. b The interaction between miR-488 and CCND1 was confirmed by dual-luciferase reporter assay. c The protein level of CCND1 in Cal-27 and SCC9 cells with miR-488 overexpression was detected by western blot. d The protein level of CCND1 in Cal-27 and SCC9 cells transfected with sh-circ_0000745#1 + anti-NC, sh-NC + anti-NC or sh-circ_0000745#1 + anti-miR-488 was detected by western blot. **P < 0.01 and ***P < 0.001

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