Skip to main content
Fig. 8 | Cancer Cell International

Fig. 8

From: Circ_0000745 strengthens the expression of CCND1 by functioning as miR-488 sponge and interacting with HuR binding protein to facilitate the development of oral squamous cell carcinoma

Fig. 8

Circ_0000745 downregulation inhibited OSCC cell growth by decreasing the level of CCND1. a The efficiency of CCND1 overexpression was checked by western blot. In Cal-27 and SCC9 cells transfected with sh-NC + vector, sh-circ_0000745#1 + vector or circ_0000745#1 + CCND1, cell proliferation was monitored by (b) CCK-8 assay and (c) colony formation assay. d, e Cell apoptosis and cell cycle distribution in these cells were investigated by flow cytometry assay. f The protein levels of PCNA, Cleaved-caspase 3 and CCND1 in these cells were quantified by western blot. *P < 0.05, **P < 0.01 and ***P < 0.001

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us