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Fig. 1 | Cancer Cell International

Fig. 1

From: Targeting a novel LncRNA SNHG15/miR-451/c-Myc signaling cascade is effective to hamper the pathogenesis of breast cancer (BC) in vitro and in vivo

Fig. 1

LncRNA SNHG15, miR-451 and c-Myc were aberrantly expressed in BC clinical specimens and cells. The BC tissues and their paired adjacent normal tissues were collected, and Real-Time qPCR was conducted to determine the expression levels of (a) LncRNA SNHG15, (b) miR-451 and (c) c-Myc mRNA. d Western Blot analysis was employed to examine c-Myc protein levels in the clinical tissues. eg Pearson correlation analysis was used to analyze the correlations among LncRNA SNHG15, miR-451 and c-Myc in BC tissues. The BC cell lines (MDA-MB-231, MCF7, SK-BR3 and T-47D) and normal human breast epithelial cell line MCF10A were cultured in vitro, and the expression levels of (h) LncRNA SNHG15, (i) miR-451 and (j) c-Myc mRNA were determined by Real-Time qPCR. k The c-Myc protein expressions in the cells were measured by using the Western Blot analysis. Each experiment repeated at least 3 times, and *P < 0.05 indicated statistical significance

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