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Fig. 4 | Cancer Cell International

Fig. 4

From: Targeting a novel LncRNA SNHG15/miR-451/c-Myc signaling cascade is effective to hamper the pathogenesis of breast cancer (BC) in vitro and in vivo

Fig. 4

MiR-451 acted as a tumor suppressor to hinder BC progression in vitro. a, b The CCK-8 assay results indicated that miR-451 inhibited BC cell proliferation. c, d The colonies formation abilities were inhibited by overexpressing miR-451 in BC cells. e, f The Annexin V-FITC/PI double staining assay evidenced that upregulation of miR-451 induced cell apoptosis in BC cells. g By performing Western Blot, we noticed that miR-451 negatively regulated N-cadherin to inhibit EMT in BC cells. Cell mobility was evaluated by using (h) transwell and (i) wound scratch assay, respectively. Each experiment repeated at least 3 times, and *P < 0.05 indicated statistical significance

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