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Fig. 5 | Cancer Cell International

Fig. 5

From: Elevation of miR-302b prevents multiple myeloma cell growth and bone destruction by blocking DKK1 secretion

Fig. 5

miR-302b inhibits the secretion of DKK1 in MM cells and promotes the Wnt/β-catenin signaling pathway in MC3T3-E1 cells. a, b The expression levels of key proteins of the Wnt/β-catenin pathway in MC3T3-E1 cells co-cultured with RPMI 8226 or MM1.S were detected by Western blotting. RPMI 8226 and MM1.S cells were transfected with miR-302b mimics (mimics)/miR-302b mimics-control (mimics ctrl) and DKK1 overexpression vectors (DKK1)/negative control vectors (DKK1 ctrl). c, d Expression of relative protein of the Wnt/β-catenin pathway in MC3T3-E1 cells

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