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Fig.2 | Cancer Cell International

Fig.2

From: Down-regulation of cylindromatosis protein phosphorylation by BTK inhibitor promotes apoptosis of non-GCB-diffuse large B-cell lymphoma

Fig.2

BTK inhibitors down-regulated CYLD phosphorylation along with BTK phosphorylation in non-GCB -DLBCL. a–d OCI-Ly10 and HBL-1 cells were treated with DMSO or 10 μM PCI-32765 (a, b) or 10 μM ACP-196 (c, d) for 48 h, lysates were sequentially blotted with the indicated antibodies. e OCI-Ly10 and HBL-1 cells were treated with DMSO or 10 μM PCI-32765 or 10 μM ACP-196 for 72 h, cell viability was assessed using CellTiter-Glo assay. The ATP level for each cell line treated with DMSO was set at 100%. The bars represent the mean ± SD from three independent experiments. **P < 0.01

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