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Table 1 Clinical characteristics of five DLBCL patients

From: Down-regulation of cylindromatosis protein phosphorylation by BTK inhibitor promotes apoptosis of non-GCB-diffuse large B-cell lymphoma

No.

Patient ID

COO IHC

Immunophenotype

FISH

IPI scorea

Ann Arbor stageb

DLBCL1

D653661

Non-GCB

CD20 + , CD10 −, BCL6 + , MUM1 + , BCL2 + 

IGH, BCL6 and MYC not rearranged, 3 copies of BCL6 noted indicating trisomy 3q, TP53 deleted

4

III

DLBCL2

D910596

Non-GCB

CD20 + , CD10 −, BCL6-, MUM1 + , BCL2 + 

IGH, BCL6 and MYC not rearranged, one copy of IGH deleted, TP53 deleted

4

III

DLBCL3

D836558

Non-GCB

CD20 + , CD10 −, BCL6-, MUM1 + , BCL2 + 

IGH and BCL6 rearranged, TP53 deleted

5

IV

DLBCL4

D982560

Non-GCB

CD20 + , CD10 −, BCL6 −, MUM1 −, BCL2-

IGH, BCL6 and MYC not rearranged, TP53 deleted

4

III

DLBCL5

D987446

Non-GCB

CD20 + , CD10 −, Bcl-6 + , MUM1 + , BCL2 + 

IGH and BCL6 rearranged, BCL2 or MYC not rearrangment, TP53 deletion

3

III

  1. aIPI score, International Prognostic Index score
  2. bAnn Arbor stage according to Ann Arbor-Cotswald staging (1989)