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Fig. 1 | Cancer Cell International

Fig. 1

From: Feedback activation of NF-KB signaling leads to adaptive resistance to EZH2 inhibitors in prostate cancer cells

Fig. 1

In silico identification of EZH2-regulated genes in PCa cells. a The microarray data from LNCaP cells treated with DMSO or EPZ6438 was used to examine the differentially expressed mRNAs. 887 differentially expressed genes including 437 up-regulated and 450 down-regulated were identified by the Limma R package and selected to draw a volcano plot. b The microarray data from LNCaP cells transfected with con-siRNA or EZH2-siRNA was used to examine the differentially expressed mRNAs. 289 differentially expressed genes including 193 up-regulated and 96 down-regulated were identified by the Limma R package and selected to draw a volcano plot. c The intersection of the common up-regulated genes in LNCaP cells after EZH2 inhibition or knockdown identified 35 potential substrates of EZH2. d The KEGG pathway analysis of these potential EZH2 substrates

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Cancer Cell International

ISSN: 1475-2867

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