Fig. 5
A subgroup featuring TMBlowMSIhigh showed prolonged OS. a The correlation between survival-related TRGs and MSI. HHEX was downregulated in tumor tissues (GSE28735) and positively associated with prolonged OS (E-MTAB-6134). b The OS of patients with TMBlowMSIhigh was significantly increased compared with that of other subtypes (P < 0.05). c ANKRD55 is significantly overexpressed in the TMBlowMSIhigh subtype and positively associated with prolonged OS. d, e ANKRD55 is universally upregulated in PDAC tissues compared with normal pancreatic tissues using immunohistochemical staining. f ANKRD55 is overexpressed in the stroma and morphologically normal pancreatic ductal structures. g The IHC scores of ANKRD55 is significantly decreased in PDAC samples compared with normal adjacent tissues (P = 0.0018). h The mRNA level of ANKRD55 is significantly downregulated in PDAC samples compared with normal adjacent tissues (P = 0.0002)