Table 3 Univariable and multivariable analyses to determine independent predictors of DFS and OS in LARC patients
From: High CFP score indicates poor prognosis and chemoradiotherapy response in LARC patients
| Â | OS | P value | Â | P value | DFS | P value | Â | P value |
|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
HR (95%CI) | HR (95%CI) | HR (95%CI) | HR (95%CI) | |||||
Gender (male vs female) | 0.289 (0.064–1.301) | 0.106 | – | – | 0.594 (0.221–1.598) | 0.303 | – | – |
Age, years | 1.019 (0.976–1.064) | 0.383 | – | – | 1.006 (0.974–1.039) | 0.725 | – | – |
Tumor site | – | 0.736 | – | – | - | 0.272 | – | – |
Low vs Upper | 0.529 (0.107–2.625) | 0.436 | – | – | 0.447 (0.144–1.398) | 0.164 | – | – |
Middle vs Upper | 0.757 (0.205–2.802) | 0.677 | – | – | 0.478 (0.178–1.279) | 0.141 | – | – |
Tumor size (> 5 vs ≤ 5) | 3.119 (0.990–9.822) | 0.052 | – | – | 3.819 (1.507–9.679) | 0.005 | – | – |
ypTNM (0-I vs II-III) | 5.357 (1.505–19.070) | 0.010 | – | – | 10.853 (3.224–36.529) |  < 0.001 | 4.785 (1.274–17.966) | 0.020 |
LNH | 0.999 (0.901–1.107) | 0.980 | – | – | 1.035 (0.957–1.119) | 0.385 | – | – |
LVI (+ vs −) | 11.976 (3.712–38.637) |  < 0.001 | 7.019 (2.117–23.267) | 0.001 | 6.990 (2.311–21.140) | 0.001 | – | – |
Perineural invasion (+ vs −) | 6.505 (2.340–18.087) |  < 0.001 | – | – | 5.077 (2.210–11.661) |  < 0.001 | 4.904 (1.475–16.301) | 0.009 |
Tumor deposit (+ vs −) | 4.476 (1.569–12.768) | 0.005 | – | – | 6.867 (3.061–15.406) |  < 0.001 | 7.932 (2.731–23.038) |  < 0.001 |
CEA (High vs Low) | 3.891 (1.316–11.507) | 0.014 | – | – | 2.160 (0.806–5.791) | 0.126 | – | – |
FARI (High vs Low) | 6.495 (2.349–17.959) |  < 0.001 | – | – | 7.274 (3.171–16.686) |  < 0.001 | 3.642 (1.316–10.081) | 0.013 |
PNI (Low vs High) | 7.764 (2.643–22.810) |  < 0.001 | – | – | 3.922 (1.753–8.773) | 0.001 | – | – |
CFP (High vs Low) | 8.117 (2.288–28.789) | 0.001 | 6.606 (1.786–23.705) | 0.005 | 4.994 (2.135–11.682) |  < 0.001 | 6.635 (1.934–22.767) | 0.003 |