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Table 3 Univariable and multivariable analyses to determine independent predictors of DFS and OS in LARC patients

From: High CFP score indicates poor prognosis and chemoradiotherapy response in LARC patients

  OS P value   P value DFS P value   P value
Univariate Multivariate Univariate Multivariate
HR (95%CI) HR (95%CI) HR (95%CI) HR (95%CI)
Gender (male vs female) 0.289 (0.064–1.301) 0.106 0.594 (0.221–1.598) 0.303
Age, years 1.019 (0.976–1.064) 0.383 1.006 (0.974–1.039) 0.725
Tumor site 0.736 - 0.272
Low vs Upper 0.529 (0.107–2.625) 0.436 0.447 (0.144–1.398) 0.164
Middle vs Upper 0.757 (0.205–2.802) 0.677 0.478 (0.178–1.279) 0.141
Tumor size (> 5 vs ≤ 5) 3.119 (0.990–9.822) 0.052 3.819 (1.507–9.679) 0.005
ypTNM (0-I vs II-III) 5.357 (1.505–19.070) 0.010 10.853 (3.224–36.529)  < 0.001 4.785 (1.274–17.966) 0.020
LNH 0.999 (0.901–1.107) 0.980 1.035 (0.957–1.119) 0.385
LVI (+ vs −) 11.976 (3.712–38.637)  < 0.001 7.019 (2.117–23.267) 0.001 6.990 (2.311–21.140) 0.001
Perineural invasion (+ vs −) 6.505 (2.340–18.087)  < 0.001 5.077 (2.210–11.661)  < 0.001 4.904 (1.475–16.301) 0.009
Tumor deposit (+ vs −) 4.476 (1.569–12.768) 0.005 6.867 (3.061–15.406)  < 0.001 7.932 (2.731–23.038)  < 0.001
CEA (High vs Low) 3.891 (1.316–11.507) 0.014 2.160 (0.806–5.791) 0.126
FARI (High vs Low) 6.495 (2.349–17.959)  < 0.001 7.274 (3.171–16.686)  < 0.001 3.642 (1.316–10.081) 0.013
PNI (Low vs High) 7.764 (2.643–22.810)  < 0.001 3.922 (1.753–8.773) 0.001
CFP (High vs Low) 8.117 (2.288–28.789) 0.001 6.606 (1.786–23.705) 0.005 4.994 (2.135–11.682)  < 0.001 6.635 (1.934–22.767) 0.003
  1. HR hazard ratio, CI cofidence interval, LNH lymph node harvest, LVI lymphovascular invasion, PNI perineural invasion, CEA carcinoembryonic antigen, PNI prognostic nutritional index, FARI Fibrinogen–Albumin Ratio Index, CFP CEA-FARI-PNI score