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Table 3 Univariable and multivariable analyses to determine independent predictors of DFS and OS in LARC patients

From: High CFP score indicates poor prognosis and chemoradiotherapy response in LARC patients

 

OS

P value

 

P value

DFS

P value

 

P value

Univariate

Multivariate

Univariate

Multivariate

HR (95%CI)

HR (95%CI)

HR (95%CI)

HR (95%CI)

Gender (male vs female)

0.289 (0.064–1.301)

0.106

0.594 (0.221–1.598)

0.303

Age, years

1.019 (0.976–1.064)

0.383

1.006 (0.974–1.039)

0.725

Tumor site

0.736

-

0.272

Low vs Upper

0.529 (0.107–2.625)

0.436

0.447 (0.144–1.398)

0.164

Middle vs Upper

0.757 (0.205–2.802)

0.677

0.478 (0.178–1.279)

0.141

Tumor size (> 5 vs ≤ 5)

3.119 (0.990–9.822)

0.052

3.819 (1.507–9.679)

0.005

ypTNM (0-I vs II-III)

5.357 (1.505–19.070)

0.010

10.853 (3.224–36.529)

 < 0.001

4.785 (1.274–17.966)

0.020

LNH

0.999 (0.901–1.107)

0.980

1.035 (0.957–1.119)

0.385

LVI (+ vs −)

11.976 (3.712–38.637)

 < 0.001

7.019 (2.117–23.267)

0.001

6.990 (2.311–21.140)

0.001

Perineural invasion (+ vs −)

6.505 (2.340–18.087)

 < 0.001

5.077 (2.210–11.661)

 < 0.001

4.904 (1.475–16.301)

0.009

Tumor deposit (+ vs −)

4.476 (1.569–12.768)

0.005

6.867 (3.061–15.406)

 < 0.001

7.932 (2.731–23.038)

 < 0.001

CEA (High vs Low)

3.891 (1.316–11.507)

0.014

2.160 (0.806–5.791)

0.126

FARI (High vs Low)

6.495 (2.349–17.959)

 < 0.001

7.274 (3.171–16.686)

 < 0.001

3.642 (1.316–10.081)

0.013

PNI (Low vs High)

7.764 (2.643–22.810)

 < 0.001

3.922 (1.753–8.773)

0.001

CFP (High vs Low)

8.117 (2.288–28.789)

0.001

6.606 (1.786–23.705)

0.005

4.994 (2.135–11.682)

 < 0.001

6.635 (1.934–22.767)

0.003

  1. HR hazard ratio, CI cofidence interval, LNH lymph node harvest, LVI lymphovascular invasion, PNI perineural invasion, CEA carcinoembryonic antigen, PNI prognostic nutritional index, FARI Fibrinogen–Albumin Ratio Index, CFP CEA-FARI-PNI score