Fig. 9

The role of circ_NRIP1 in tumor growth of ESCC cells in vivo. a Tumor volume was measured every five days after implantation of KYSE450 cells stably expressed shRNA against circ_NRIP1 or negative control sequences (simplified as sh-circ_NRIP1 or sh-NC) for 10 days. b Tumor weight was recorded on the last day. c–f RT-qPCR detected c circ_NRIP1, d miR-595, e SEMA4D mRNA levels, and western blotting measured f SEMA4D protein level in tumor tissues from xenograft mice. *P < 0.05