Table 3 Clinical and molecular characteristics of 2 primary pediatric T-ALL
Case | Gender | Age (y) | Karyotype comments | Fusion Gene | Mutation | Initial BM blast (%) | WBC (× 109/L) | D15th BM blast (%) | D33th BM blast (%) |
|---|---|---|---|---|---|---|---|---|---|
1 | Male | 3.75 | 88–92,XY, + X, + Y, + 1 × 2, + 2 × 2, + 3 × 2, + 4 × 2, + 5 × 2, + 6 × 2, + 7 × 2, + 8 × 2, + 9 × 2 + ……. + 22 × 2 | PICALM/MLLT10 | None | 88 | 122.82 | 92 | 47 |
2 | Female | 10.25 | 46,XX,t (10,11) (p13,q23), add (15) (q25)/46,idem, + mar | DDX3X/MLLT10 | NOTCH1 (41.2%),NRAS (80.7%) | 89 | 35.33 | 82 | 21 |