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Table 3 Clinical and molecular characteristics of 2 primary pediatric T-ALL

From: BRD4 PROTAC degrader ARV-825 inhibits T-cell acute lymphoblastic leukemia by targeting 'Undruggable' Myc-pathway genes

Case Gender Age (y) Karyotype comments Fusion Gene Mutation Initial BM blast (%) WBC (× 109/L) D15th BM blast (%) D33th BM blast (%)
1 Male 3.75 88–92,XY, + X, + Y, + 1 × 2, + 2 × 2, + 3 × 2, + 4 × 2, + 5 × 2, + 6 × 2, + 7 × 2, + 8 × 2, + 9 × 2 + ……. + 22 × 2 PICALM/MLLT10 None 88 122.82 92 47
2 Female 10.25 46,XX,t (10,11) (p13,q23), add (15) (q25)/46,idem, + mar DDX3X/MLLT10 NOTCH1 (41.2%),NRAS (80.7%) 89 35.33 82 21