Fig. 7

Effect of ICA on cell proliferation-related proteins in U14 tumor-bearing mice model. a Western blot analysis of P16, P53, Bax, Ki67, survivin, Bcl-2, and c-Myc proteins in tumor tissues of U14 tumor-bearing mice model that treated with CTX or ICA. b–d CTX and ICA increased P16, P53, and Bax protein expressions in tumor tissues in a dose-dependent manner. e–h Treating with ICA dose-dependently reduced Ki67, survivin, Bcl-2, and c-Myc levels in mice models. Results are means ± SD, n = 5; ^*P < 0.05; ^**P < 0.01 vs model group