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Fig. 3 | Cancer Cell International

Fig. 3

From: MicroRNA-665 facilitates cell proliferation and represses apoptosis through modulating Wnt5a/β-Catenin and Caspase-3 signaling pathways by targeting TRIM8 in LUSC

Fig. 3

miR-665 downregulates TRIM8 expression through targeting its 3′-UTR. a Bioinformatics predicted the binding sites of miR-665 in the 3′-UTR of TRIM8. b Luciferase activity was detected by using the dual-luciferase assay. c TCGA data showed the TRIM8 expressions in human LUSC tissues. d qRT-PCR assay revealed the TRIM8 mRNA expressions in LUSC tissues. e TRIM8 protein levels were measured by Western blotting. f The expressions of miR-665 and TRIM8 were negatively correlated. The 2−ΔΔCt values of miR-665 and TRIM8 mRNA were subjected to a Spearman correlation analysis (r = − 0.3211, n = 69, p = 0.0071). n = 3, *p < 0.01, **p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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