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Fig. 4 | Cancer Cell International

Fig. 4

From: MicroRNA-665 facilitates cell proliferation and represses apoptosis through modulating Wnt5a/β-Catenin and Caspase-3 signaling pathways by targeting TRIM8 in LUSC

Fig. 4

miR-665 regulates the Wnt5a/β-Catenin and Caspase-3 signaling pathways in human LUSC cells by targeting TRIM8. a TRIM8 mRNA was measured in NCI-H226/SK-MES-1 cells after transfection with the miR-665 mimics. b TRIM8 mRNA was determined in NCI-H226/SK-MES-1 cells after transfection with the miR-665 inhibitor. c miR-665 mimics facilitated the expression of Wnt5a, β-Catenin, c-Myc and Cyclin D1 proteins, and repressed active Caspase-3 protein expression. d miR-665 inhibitor suppressed the expression of Wnt5a, β-Catenin, c-Myc and Cyclin D1 proteins, and enhanced active Caspase-3 protein expression. n = 3, **p < 0.001

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